3.5.1. (E)-3-(3-Hydroxy-1,3-diphenylpropylidene)-1-methylindolin-2-one (**8aa**)

91% Yield; yellow foam; *R*<sup>f</sup> = 0.37 (silica gel, hexane:EtOAc = 2:1); 1H NMR (500 MHz, CDCl3): *δ* 7.57–7.43 (m, 4H), 7.40 (d, *J* = 7.4 Hz, 2H), 7.31 (t, *J* = 7.5 Hz, 2H), 7.27–7.19 (m, 2H), 7.15 (t, *J* = 7.6 Hz, 1H), 6.79 (d, *J* = 7.7 Hz, 1H), 6.66 (t, *J* = 7.6 Hz, 1H), 6.14 (d, *J* = 7.7 Hz, 1H), 4.82 (d, *J* = 9.8 Hz, 1H), 4.50 (s, 1H), 4.42 (dd, *J* = 12.6, 11.0 Hz, 1H), 3.30 (s, 3H), 2.88 (dd, *J* = 12.8, 2.8 Hz, 1H) ppm; 13C NMR (125 MHz, CDCl3): *δ* 169.6, 155.6, 145.5, 142.3, 141.3, 129.6, 129.1, 128.9, 128.7, 128.5, 127.3, 126.5, 126.3, 125.7, 123.0, 122.8, 122.1, 108.0, 73.7, 46.0, 26.2 ppm; HRMS (EI): calcd for C24H21NO2 [M+] : 355.1572, found 355.1568.

3.5.2. (E)-3-(3-Hydroxy-1-(4-methoxyphenyl)-3-phenylpropylidene)-1-methylindolin-2-one (**8da**)

93% Yield; yellow foam; *R*<sup>f</sup> = 0.18 (silica gel, hexane:EtOAc:CH2Cl2 = 4:1:1); 1H NMR (500 MHz, CDCl3): *δ* 7.42 (dd, *J* = 13.8, 7.3 Hz, 3H), 7.33 (dd, *J* = 10.4, 4.8 Hz, 2H), 7.26–7.19 (m, 2H), 7.19–7.13 (m, 1H), 7.09–6.96 (m, 2H), 6.81 (d, *J* = 7.7 Hz, 1H), 6.71 (td, *J* = 7.7, 1.0 Hz, 1H), 6.38 (d, *J* = 7.4 Hz, 1H), 4.82–4.73 (m, 1H), 4.65 (d, *J* = 7.7 Hz, 1H), 4.39 (dd, *J* = 12.8, 10.8 Hz, 1H), 3.92 (s, 3H), 3.32 (s, 3H), 2.88 (dd, *J* = 12.8, 2.9 Hz, 1H) ppm; 13C NMR (125 MHz, CDCl3): *δ* 169.8, 160.4, 156.1, 145.7, 142.2, 133.2, 130.7, 128.53, 128.48, 128.0, 127.3, 126.3, 125.7, 123.1, 122.8, 122.1, 115.1, 114.3, 108.1, 74.1, 55.5, 46.3, 26.2 ppm; HRMS (EI): calcd for C25H21NO2 [M-H2O]+ : 367.1572, found 367.1567.

3.5.3. (E)-3-(3-(4-Chlorophenyl)-3-hydroxy-1-(4-methoxyphenyl)propylidene)-1 methylindolin-2-one (**8db**)

75% Yield; orange foam; *R*<sup>f</sup> = 0.38 (silica gel, hexane:EtOAc:CH2Cl2 = 4:1:1); 1H NMR (500 MHz, CDCl3): *δ* 7.39 (d, *J* = 7.8 Hz, 1H), 7.35–7.22 (m, 4H), 7.18 (dd, *J* = 15.7, 8.0 Hz, 2H), 7.00 (dd, *J* = 22.8, 8.2 Hz, 2H), 6.80 (d, *J* = 7.7 Hz, 1H), 6.71 (t, *J* = 7.6 Hz, 1H), 6.38 (d, *J* = 7.7 Hz, 1H), 4.78 (s, 2H), 4.32–4.19 (m, 1H), 3.90 (s, 3H), 3.30 (s, 3H), 2.97–2.88 (m, 1H) ppm; 13C NMR (125 MHz, CDCl3): *δ* 169.7, 160.4, 155.6, 144.1, 142.2, 133.0, 132.8, 130.5, 128.6, 128.5, 128.1, 127.1, 126.4, 123.0, 122.8, 122.2, 115.0, 114.3, 108.1, 73.4, 55.5, 46.2, 26.2 ppm; HRMS (EI): calcd for C25H20ClNO2 [M-H2O]+ : 401.1183, found 401.1183.

3.5.4. (E)-3-(3-Hydroxy-1-(4-methoxyphenyl)-3-(4-nitrophenyl)propylidene)-1 methylindolin-2-one (**8dc**)

86% Yield; orange foam; *R*<sup>f</sup> = 0.20 (silica gel, hexane:EtOAc:CH2Cl2 = 4:1:1); 1H NMR (500 MHz, CDCl3): *δ* 8.14 (d, *J* = 8.5 Hz, 2H), 7.54 (d, *J* = 8.4 Hz, 2H), 7.39 (d, *J* = 7.7 Hz, 1H), 7.19 (t, *J* = 7.5 Hz, 2H), 7.00 (t, *J* = 9.6 Hz, 2H), 6.82 (d, *J* = 7.7 Hz, 1H), 6.73 (t, *J* = 7.6 Hz, 1H), 6.41 (d, *J* = 7.7 Hz, 1H), 5.18 (d, *J* = 6.7 Hz, 1H), 5.00–4.86 (m, 1H), 4.17 (dd, *J* = 12.7, 10.4 Hz, 1H), 3.90 (s, 3H), 3.32 (s, 3H), 3.05 (dd, *J* = 12.8, 2.5 Hz, 1H) ppm; 13C NMR (125 MHz, CDCl3): *δ* 169.8, 160.6, 154.7, 153.0, 147.1, 142.2, 132.8, 130.5, 128.8, 128.3, 126.8, 126.5, 123.7, 122.83, 122.81, 122.4, 115.0, 114.5, 108.3, 73.4, 55.5, 45.9, 26.3 ppm; HRMS (EI): calcd for C25H20N2O4 [M-H2O]+ : 412.1423, found 412.1421.
