**5. Conclusions**

The qualitative characterization of the extracellular enzyme activities, the antagonism of the *Streptomyces* spp. strains, as well as the in vivo studies against *M. phaseolina* and *R. solani* under semi-controlled conditions have allowed us to characterize promising strains as BCAs, and to have a biological alternative in the framework of the integrated management of the main common bean diseases caused by soil pathogens in Cuba. To confirm our laboratory results, the research should and will be evaluated under natural field conditions in further studies.

**Author Contributions:** Experimental and laboratory tasks, data analysis, wrote and edit the manuscript, M.D.-D.; supervising, review and edit the manuscript, A.B.-C.; review the manuscript, A.T.; sampling, isolation and collection of the actinobacterial strains used in this study, R.M.-M.; experimental design and data analysis, S.S.-R.; experimental and laboratory tasks, R.D.C.-S., isolation of actinobacterial strains, M.G.-B., data analyses, review and edit the manuscript, funding for Open Access publishing, C.A.-B. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research was financially supported by the Institutional Project 9453: "Search for new strains of actinomycetes that produce antibiotics" of the Center of Chemical Bioactives (CBQ) of the Central University "Marta Abreu" de Las Villas (UCLV), Cuba. M.D-D is holder of scholarships from the Ibero-American University Association for Postgraduate Studies (AUIP) to carry out her pre-doctoral stages (3 stages of 3 months) at the Department of Agronomy at the University of Córdoba (UCO; Spain). We also acknowledge financial support from the Spanish Ministry of Science and Innovation, the Spanish State Research Agency, through the Severo Ochoa and María de Maeztu Program for Centres and Units of Excellence in R&D (Ref. CEX2019-000968-M).

**Institutional Review Board Statement:** Not applicable.

**Informed Consent Statement:** Not applicable.

**Data Availability Statement:** The data that support the findings of this study are available from the corresponding author upon reasonable request.

**Acknowledgments:** The authors thank the Center of Chemical Bioactives (CBQ) of the Central University "Marta Abreu" de Las Villas (UCLV; Cuba) since all the Streptomyces strains used in this study were donated by the CBQ to develop the present study. The authors thank Edisleidy Águila Jiménez, Yoandry Arencibia, Eliannys Rodríguez Soris and Juan Pablo Mesa Marcillas and Technician Marlén Casanova González for their skillful technical assistance, as well as the colleagues of Department of Agronomy of the University of Córdoba (Spain) for host during the pre-doctoral stages.

**Conflicts of Interest:** The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

#### **References**

