Kinetic Model Profiling

The drug release data were fitted into a Korsmeyer–Peppas kinetic model to investigate the mechanism of drug release [31,32]. The power-law equation is shown below

$$\mathbf{Mt}/\mathbf{M}\infty = \mathbf{Kt}^{\circ}\mathbf{n} \tag{6}$$

where Mt and M∞ are the fractions of drug released after time t.

K represents the constant rate.

n represents the exponential release value.

When n = 0.5, it is a quasi-Fickian diffusion mechanism.

When n > 0.5, drug release occurred by an anomalous non-Fickian, Case II or zeroorder release mechanism

When n = 0, it indicates a zero-order release mechanism.
