**3. Results and Discussion**

## *3.1. Synthesis*

In this article, we report the successful synthesis of four ketoprofen hybrid molecules with different *N*-containing compounds, such as pyrrolidine **1a**, piperidine **1b**, 1,2,3,4 tetrahydroquinoline **1c**, and 1,2,3,4-tetrahydroisoquinoline **1d** (Figure 1), as shown in Scheme 1. In Scheme 1, we report the synthesis of four novel ketoprofen hybrid compounds. Ning and co-workers report the synthesis and characterization of the fluorinated product of compound **3a** [40]. The second reported by us, molecule **3b**, partially consists of the molecule reported by a group of Turkish scientists [41]. There was no information available in chemical databases for compounds **3c** and **3d**.

**Scheme 1.** Synthesis of hybrids **3a**–**d**.
