2.4.1. Determination of Lipophilicity as RM Values

The lipophilicity of the furan derivatives was estimated using the method described by Hadjipavlou-Litina and Pontiki [17].

RPTLC (reverse-phase TLC) was performed on silica gel plates impregnated with 55% (*v*/*v*) liquid paraffin in light petroleum ether. The mobile phase was a methanol/water mixture (77:23, *v*/*v*) containing 0.1 acetic acid. The plates were developed in closed chromatography tanks saturated with the mobile phase at 24 ◦C. Spots were detected under UV light or by iodine vapors. RM values were determined from the corresponding Rf values (from 10 individual measurements) using the equation RM = log [(1/Rf) − 1].
