2.2.1. Synthesis of *2-(3-benzoylphenyl)propanoyl chloride* **2**

To ketoprofen (1 mmol, 0.254 g) dissolved in toluene (30 mL), an excess of thionyl chloride (1.2 mmol, 0.087 mL) was added. The reaction mixture was stirred under reflux for two hours. The excess of thionyl chloride and the toluene were removed under reduced pressure. The obtained 2-(3-benzoylphenyl)propanoyl chloride **2** was used without further purification.
