3.3.3. Experimental Determination of Lipophilicity (RM)

Lipophilicity is a determining factor in the absorption of compounds, distribution in the body, passage through various membranes and biological barriers, metabolism, as well as excretion (these are the so-called ADME properties—absorption, distribution, metabolism, and excretion). Lipophilicity is an important factor that informs researchers to both predict and better understand the transport and importance of chemical molecules in physiological and ecological systems. It is of utmost importance for all "candidate" drugs, thanks to its extremely important role in the pharmaceutical and biotechnology industry. Lipophilicity can be measured experimentally or computed.

We used reversed-phase thin-layer chromatography to assess the lipophilicity of the resulting ketoprofen hybrids, a technique described by Hadjipavlou-Litina [49]. The results are shown in Table 1.
