Flexible Alignment

The 3D flexible alignment was studied for compound **7** and toceranib. The produced figure indicated a high degree of similarity between these compounds. Each feature in the tested compounds takes the same orientation of the corresponding one. In detail, the 5-fluoroindolin-2-one, central phenyl, amide, and terminal phenyl moieties of compound **7** showed the same orientations as 5-methoxyindolin-2-one, 2,4-dimethyl-1H-pyrrole, amide, and 1-ethylpyrrolidine moieties of toceranib, respectively (Figure 16).

**Figure 16.** Flexible alignment of compound 8 (green) with sorafenib (pink), showing the same orientation.
