**5. Conclusions**

In conclusion, the AA genotype of the *ADIPOQ variant* (rs3774261) is related to a significant increase in serum levels of adiponectin and ratio adiponectin/leptin and decrease in the lipid profile and C-reactive protein (CRP) after a hypocaloric high polyunsaturated fat Mediterranean diet.

**Author Contributions:** D.A.d.L.R. and J.J.L. designed the study and realized statistical analysis; O.I. and E.G., anthropometric status and monitoring of dietary intake; D.P. performed biochemical evaluation and genotype studies. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research did not receive any specific gran<sup>t</sup> from funding agencies in the public, commercial, or not-for-profit sectors.

**Institutional Review Board Statement:** The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Institutional Review Board (or Ethics Committee) of Hospital Clinico Universitario Valladolid committee 7/2017, code: GRS588/A/11).

**Informed Consent Statement:** Informed consent was obtained from all subjects involved in the study.

**Conflicts of Interest:** All authors have no conflict of interest.
