*4.1. General Experimental Procedures*

Genomic DNA samples were prepared using the CTAB isolation buffer at pH 8.0 (20 g/L cetyltrimethylammonium bromide, 1.4 M sodium chloride, and 20 mM EDTA). Polymerase chain reaction (PCR) was performed using Phusion® High-Fidelity DNA Polymerase (New England Biolabs, NEB, Beijing, China). PCR analyses were conducted using a 2×Hieff® PCR Master Mix (With Dye, Yeasen, Shanghai, China). DNA restriction enzymes were used as recommended by the manufacturer (New England Biolabs, NEB, Beijing, China). RT-PCR analysis was performed using Direct-zol™ RNA MiniPrep (Zymo Research, Irvine, CA, USA) and PrimeScript RT-PCR Kit (TaKaRa, Gunma, Japan). The genespecific primers are listed in Table S1. Custom oligonucleotides synthesis and fragments sequencing were served by Shanghai Sangon DNA Technologies. LC-MS was performed using an Acquity UPLC H-Class coupled to a SQ Detector 2 mass spectrometer using a BEH C18 column (1.7 μm, 2.1 × 50 mm, 1 mL/min) (Waters Corporation, Milford, MA, USA). Semi-preparative HPLC (YMC Co., Ltd., Kyoto, Japan) was performed on an ODS column (YMC-Pack ODS-A, 10 × 250 mm, 5 <sup>μ</sup>m, 3 mL/min). 1H NMR and 13C NMR spectra were recorded on an Agilent 500 MHz DD2 spectrometer (Agilent Technologies Inc., Santa Clara, CA, USA). The spectra were processed by the software MestReNova 6.1.0 (Metrelab, Coruña, Spain). NMR data are provided in Tables S3 and S4, and spectra in Figures S8–S11.
