**3. Materials and Methods**

### *3.1. General Experimental Procedures*

HRESIMS data were measured on a Finnigan LTQ-Orbitrap Elite (Thermo Fisher Scientific, Waltham, MA, USA). NMR spectra were obtained by Bruker AVANCE NEO 600 MHz spectrometer (Bruker BioSpin, Switzerland). CD spectrum was reported on a Chirascan TM CD spectropolarimeter (Applied Photophysics, U.K). Optical rotation was obtained on an MCP 500 (Anton Paar, Austria). Single-crystal data was measured on an Oxford Gemini S Ultra diffractometer (Oxford Instrument, Oxfordshire, UK). Sephadex LH-20 (25–100 μm; GE Healthcare, Bio-Sciences AB, Stockholm, Sweden) and silica gel (200–300 mesh; Qingdao Marine Chemical Factory, Qingdao, China) were used for Column chromatography (CC). Thin layer chromatography (TLC) was detected on Silica gel GF254 plate (Qingdao Marine Chemical Ltd., Qingdao, China).

#### *3.2. Fungal Material*

The fungus BJR-P2 used in this research was isolated from the barks of *Avicennia marinav* (*Forsk*.) *Vierh*, a mangrove plant which collected from Yangjiang Hailing Island Mangrove Wetland Park. Using molecular biology methods, the fungus was identified through DNA amplification and ITS region sequencing. The sequence data of this strain has been deposited in Gen Bank with accession no. PRJNA793386. The BLAST search results show that the sequence is 100% similar to that of *Penicillium* sp.
