*3.3. Extraction and Purification*

All fermentation broth (40 L) was extracted with MeOH, filtered, concentrated, and partitioned between EtOAc and H2O. The EtOAc extract was evaporated under reduced pressure to give a crude gum (18.5 g). Moreover, the extract was subjected vacuum chromatography on silica gel (200–300 mesh) and eluted with stepped gradient elution via DCM:MeOH (100:1–1:1) to yield eight combined fractions (Fr.1 to Fr.8). Fr.6 was further separated using ODS (MeOH: H2O; 30:80–100:0) to obtain Fr.6-1 to Fr.6-6. Then Fr.6-3 and Fr.6-4 were further subjected to a Sephadex LH-20 column and eluted with MeOH to provide subfractions (from Fr.6-3-1 to Fr.6-3-4 and from Fr.6-4-1 to Fr.6-4-5). Fr.6-4-2 was purified by HPLC eluted with MeCN-H2O (38:62) to give compounds **1** (4.2 mg, *tR* = 11.5 min), **2** (3.4 mg, *tR* = 7.2 min), and **5** (3.5 mg, *tR* = 8.0 min), respectively. Fr.6-3- 2 was purified by HPLC eluted with MeOH-H2O (65:35) to give compounds **3** (5.1 mg, *tR* = 10.2 min), **6** (4.3 mg, *tR* = 11.0 min), and **4** (3.2 mg, *tR* = 13.5 min), respectively.
