*3.2. Fungal Material and Fermentation*

The fungal strain HDN17-933 was isolated from Fildes Peninsula, Antarctica, and identified as *Pseudogymnoascus* sp. based on internal transcribed spacer DNA sequencing. The sequence is available with the accession number MZ268166 at Genbank. It has been submitted to the Key Laboratory of Marine Drugs, working under the Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China. The fungus was

cultured under the static condition at 15 ◦C in winter for 30 days in 1 L Erlenmeyer flasks, each containing rice (80 g) and naturally collected seawater (Huiquan Bay, Yellow Sea) (120 mL).
