**6. Conclusions**

In this review, we screened, evaluated, and discussed different chemical, physical, biological, and combined techniques to mitigate mycotoxins in solid foods and feeds. Many chemical treatments showed their effectiveness by achieving approximately a total elimination of AFs under certain conditions, such as optimized nixtamalization, ammoniation, and acid. Physical treatments such as photocatalysis and cold plasma were able to achieve the complete elimination of DON and AFB1, respectively. Chemical treatments showed higher reduction rates of mycotoxins than physical treatments, but the latter treatments were favorable from a quality perspective. Their effect was superficial, causing minimal changes in the quality of treated materials. Biological treatments are considered safe, eco-friendly, and cost-effective methods for mitigating mycotoxins. *Zygosaccharomyces rouxii* or a combination of LAB strains attained high reduction rates. Two or more treatments were used subsequently or simultaneously in order to find a synergistic effect of the combination to achieve high reduction rates in solid food materials without inducing any extreme impacts in each one. Nine combinations are presented in the last two tables, showing the higher reduction rates of aflatoxins (>90%) achieved by the following two combinations when implemented subsequently: O3/UV-C/citric acid and high H2O2 concentration treatment at moderate temperature/roasting. Other combinations were applied simultaneously, also showing their efficiency in the reduction of aflatoxins (>93%), such as citric acid with pulsed light and roasting with acid. These combinations affected the physical characteristics of the treated nuts. Future research should focus on the optimization of physical treatments to increase their mycotoxin reduction efficiency and on the elaboration of more combination possibilities to find the best synergistic effect to protect the product quality and the environment. It is highly important to focus more on implementing detoxification techniques on naturally contaminated materials than spiked or artificially contaminated materials. Natural contamination may be caused by several mycotoxins and may occur differently. Furthermore, these studies should examine the effectiveness of these techniques at the industrial scale more than at the laboratory scale.

**Funding:** This research received no external funding.

**Data Availability Statement:** Data is contained within the article.

**Conflicts of Interest:** The authors declare no conflict of interest.
