*Review* **Biocontrol of** *Candida albicans* **by Antagonistic Microorganisms and Bioactive Compounds**

**Honghua Li <sup>1</sup> , Jinpeng Yang <sup>2</sup> , Xinwan Zhang <sup>2</sup> , Xiuli Xu <sup>2</sup> , Fuhang Song 1,\* and Hehe Li 1,3,\***

	- <sup>2</sup> School of Ocean Sciences, China University of Geosciences, Beijing 100083, China

**Abstract:** *Candida albicans* is an endogenous opportunistic pathogenic fungus that is harmless when the host system remains stable. However, *C. albicans* could seriously threaten human life and health when the body's immune function declines or the normal flora is out of balance. Due to the increasing resistance of candidiasis to existing drugs, it is important to find new strategies to help treat this type of systemic fungal disease. Biological control is considered as a promising strategy which is more friendly and safer. In this review, we compare the bacteriostatic behavior of different antagonistic microorganisms (bacteria and fungi) against *C. albicans*. In addition, natural products with unique structures have attracted researchers' attention. Therefore, the bioactive nature products produced by different microorganisms and their possible inhibitory mechanisms are also reviewed. The application of biological control strategies and the discovery of new compounds with antifungal activity will reduce the resistance of *C. albicans*, thereby promoting the development of novel diverse antifungal drugs.

**Citation:** Li, H.; Yang, J.; Zhang, X.; Xu, X.; Song, F.; Li, H. Biocontrol of *Candida albicans* by Antagonistic Microorganisms and Bioactive Compounds. *Antibiotics* **2022**, *11*, 1238. https://doi.org/10.3390/ antibiotics11091238

Academic Editor: William N. Setzer

Received: 30 July 2022 Accepted: 9 September 2022 Published: 12 September 2022

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**Keywords:** *Candida albicans*; antagonistic microorganisms; biocontrol strategy; bioactive compounds
