*Review* **The Role of Digital Tools in the Timely Diagnosis and Prevention of Acute Exacerbations of COPD: A Comprehensive Review of the Literature**

**Athanasios Konstantinidis 1, Christos Kyriakopoulos 1,\*, Georgios Ntritsos 2,3, Nikolaos Giannakeas 3, Konstantinos I. Gourgoulianis 4, Konstantinos Kostikas <sup>1</sup> and Athena Gogali <sup>1</sup>**


**Abstract:** Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the airways and lung parenchyma with multiple systemic manifestations. Exacerbations of COPD are important events during the course of the disease, as they are associated with increased mortality, severe impairment of health-related quality of life, accelerated decline in lung function, significant reduction in physical activity, and substantial economic burden. Telemedicine is the use of communication technologies to transmit medical data over short or long distances and to deliver healthcare services. The need to limit in-person appointments during the COVID-19 pandemic has caused a rapid increase in telemedicine services. In the present review of the literature covering published randomized controlled trials reporting results regarding the use of digital tools in acute exacerbations of COPD, we attempt to clarify the effectiveness of telemedicine for identifying, preventing, and reducing COPD exacerbations and improving other clinically relevant outcomes, while describing in detail the specific telemedicine interventions used.

**Keywords:** telemedicine; telehealth; telemonitoring; COPD; acute exacerbation COPD;diagnosis; prevention
