*2.3. Evaluation Parameters*

### 2.3.1. pH

The standard pH range of the oral mucosa is 6.0 to 7.0 and the gel pH values were found to be 6.4.

### 2.3.2. Homogeneity

There were no lumps or grittiness in any of the gel formulations that were made. (Table 2).

### 2.3.3. Spreadability

After 1 min, the spreadability of the gels ranged from 10.73 ± 0.01 mm to 23.75 ± 0.03 mm. The gel formulations were prepared with Carbopol 934, and hence demonstrated high spreadability and extrudability (Table 2).

### 2.3.4. Drug Content Uniformity

The percentage drug content of all formulations ranged from 0.2 ± 0.01% mg/g to 32.77 ± 0.20% mg/g (Table 2) The drug content was consistent across all gels.

### 2.3.5. Stability

Physiological changes such as change in color, or segregation of fluid exudates of the gels were not observed after 6 months of stability studies. The pH of all the gels was unaffected and ranged from 6.5 ± 0.03 to 7.0 ± 0.06. After 6 months, and the drug content ranged from 0.17 ± 0.19 to 28.00 ± 0.004% mg/g (Table 2). The results are expressed as mean ± SD, where *n* = 3 and SD stands for standard deviation.

### *2.4. In Vitro Drug Diffusion Studies*

Cumulative percent drug release ranged from 21.97 ± 0.02% for the open-ended cylinder and cumulative percent drug release ranged from 65.71 ± 0.04% for the diffusion cell apparatus across all formulations (Figure 3). As a result, F10 was chosen as the optimal formulation.
