**5. Conclusions**

The present systematic review highlights a potential role of HPV in the development of bladder cancer, indirectly supporting the adoption of primary preventive strategies in both sexes, as recommended by international authorities. Further epidemiological studies are needed to confirm those findings and assess the role of diagnostic and preventive strategies for HPV-related bladder cancer.

**Supplementary Materials:** The following supporting information can be downloaded at: https: //www.mdpi.com/article/10.3390/diagnostics12071759/s1, Figures S1–S3, Tables S1–S5.

**Author Contributions:** Conceptualization, N.M., B.D.L., L.S. and G.S.; methodology, N.M., B.D.L., L.S., A.P. and G.S.; software, B.D.L., L.S. and G.S.; validation, N.M., B.D.L., L.S., I.S., A.P. and G.S.; formal analysis, B.D.L., L.S. and G.S.; investigation, N.M., B.D.L., G.S.; resources, N.M., B.D.L., L.S., I.S., A.D.R., A.P. and G.S.; data curation, N.M., B.D.L., L.S., A.P. and G.S.; writing—original draft preparation, N.M., B.D.L., I.S. and A.D.R.; writing—review and editing, N.M., B.D.L., A.P. and G.S.; visualization, N.M., B.D.L., L.S., I.S., A.D.R., A.P. and G.S.; supervision, A.P. and G.S. All authors have read and agreed to the published version of the manuscript.

**Funding:** Article Processing Charge was funded by Cariplo Foundation-Biomedical Research conducted by Young Researchers 2019.

**Institutional Review Board Statement:** Ethical review and approval were waived due to the design of the study.

**Informed Consent Statement:** Patient consent was waived due to the design of the study.

**Data Availability Statement:** The data is available in case it is requested for motivated reasons.

**Conflicts of Interest:** The authors declare no conflict of interest.
