*Statistical Analysis*

Patients' history, characteristics at diagnosis, therapeutic pathway and follow-up occurrences were summarized as the count and percentage for the categorical variables, as a mean and range for the continuous variables, and as the median and range for the skewed variables. The cumulative incidence function (CIF) of the CV localization was computed considering death as a competing event. The overall survival was estimated by the Kaplan–Meier (KM) method, and a survival curve was represented. Statistical analyses were performed using SAS statistical software version 9.4 (SAS Institute Inc., Cary, NC, USA).
