**3. Statistical Analysis**

Patients' characteristics were summarized either by count and percent or mean and standard deviation (SD) for categorical and continuous variables, respectively. Methods agreement was estimated using Cohen's kappa coefficient and Lin's correlation. Lesion size (maximum diameter) differences between VGS and MRI with respect to histology were summarized by mean, SD, and 95% confidence intervals (95% CI) and compared using Bland–Altman and Passing–Bablok regression methods. All method comparisons considered histology as the gold standard. Cross-tabulation of the categorical variables was tested for significance using Fisher's exact test; the mean comparison was made using the unpaired t-test. All tests were two-tailed and considered significant at the 5% level. All analyses were done using SAS 9.4 (NC, Cary) and STATA (StataCorp., College Station, Texas, USA, 2021. Stata Statistical Software: Release 17. College Station, TX: StataCorp LLC).
