*2.4. Cobas 4800 HPV Test*

Cobas is a real-time PCR-based test able to detect HR-HPV genotypes: HPV 16 and 18 are reported as single genotypes, as well as a group of 12 other HR-HPV types (31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68) are reported as HR positive readout. This fully automated test detects the same genotypes of HC2, which have been classified as HR by (the International Agency for Research on Cancer (IARC)), and in addition HPV66, and includes an internal control (B-globin) as the marker of sample adequacy.
