*2.1. Protocol and Registration*

The present systematic review and meta-analysis has been conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) [16] and Meta-analysis Of Observational Studies in Epidemiology (MOOSE) [17] statements (Supplementary Tables S1 and S2). A pre-specified protocol has been registered in the Prospero repository (CRD42022344686).
