*2.4. Image Evaluation and Segmentation*

Parametric images were produced and quantified using syngo.via® 8.2 (Siemens Healthineers, Erlangen, Germany). Volumes of interest (VOIs) were manually delineated in the fused PET/CT images and validated by a certified expert in nuclear medicine with more than five years of experience in PET/CT. VOIs were overlaid on the Ki dataset, DV-FDG, and on the static PET images for data extraction. If necessary, manual coregistration was performed to assure adequate realignment.
