*Limitations*

There are several limitations in this prospective pilot study. First, the sample size of LNM and distant metastases is relatively small, even though it represents one of the largest published collectives. However, due to large effect sizes, the data presented are significant and, therefore, might enable a pre-conclusive analysis.

In addition, some of the lesions could not be confirmed by biopsy; thus, the diagnosis had to be confirmed based on the conclusion of the interdisciplinary tumor board, as is the gold standard for many lesions.

Data acquisition was performed within a single-center study setting; thus, the intercomparability of measurements between different PET scanners cannot be evaluated.
