*2.5. Statistical Analysis*

Statistical analysis was performed using SPSS Version 22 (IBM Corporation, Armonk, NY, USA). We tested all parameters for the normality with a Kolmogorov-Smirnov test. A Mann-Whitney-U test was used to test the differences in tumor volumetric parameters, 1st order textural features and laboratory parameters between the patient groups achieving CR or PR. To address the multiple comparisons, a Benjamin Hochberg correction was applied. The adjusted *p*-values were considered significant at a level of 0.05.
