**2. Materials and Methods**

We conducted a literature search using the PubMed database. The following search terms were included "adherence" AND "glaucoma medication", "topical treatment" AND "glaucoma", drug delivery systems and glaucoma treatment, "selective laser trabeculoplasty", and "minimally invasive glaucoma surgery". The articles retrieved were reviewed for their title, abstract, and language. Articles included were in in English language published before August 2022 including clinical trials in humans, editorials, reviews, systematic reviews, and meta-analyses. We focused on randomized clinical trials (when available). After retrieving relevant articles using keywords, a search was performed through the reference lists of the chosen studies and additional papers were selected.
