*3.1. Distinctin*

Distinctin is an amphipathic antimicrobial peptide that has a structure characterised by two different peptide chains connected by a disulfide bridge. It has been isolated from the skin of *Phyllomedusa distincta* and has shown good antimicrobial activity in vitro. The in vitro efficacy was also confirmed in vivo. In fact, this molecule demonstrated efficacy when administered intravenously in neutropenic mouse models infected with *Staphylococcus aureus*, either alone or in combination with other antibiotics. Notably, its efficacy was shown to be highest when administered together with glycopeptides in the absence of toxic events related to the administration of the peptide itself. Distinctin in combination with vancomycin and teicoplanin resulted in the lowest lethality rate in the aforementioned models [39].
