*7.3. Tachyplesin III*

As seen against Gram-negatives, Tachyplesin III was also evaluated in mycotic dermatophyte infections in vitro. Terbinafine had a significantly lower MIC than Tachyplesin III (*p* < 0.001). The combination of the two therapies showed synergistic activity in 30% of cases, and no antagonism was recorded. Interestingly, both Tachyplesin III and terbinafine significantly reduced growth in *M. canis* (*p* < 0.01) [94]. This AMP could therefore be useful in combination with terbinafine to lower the dose of the antifungal while maintaining efficacy and safety.
