*Article* **Curative Effects of Copper Iodide Embedded on Gallic Acid Incorporated in a Poly(vinyl alcohol) (PVA) Liquid Bandage**

**Putita Phetcharat <sup>1</sup> , Pakakrong Sangsanoh 1,2, Chasuda Choipang 1,2, Sonthaya Chaiarwut 1,2 , Orawan Suwantong 3,4 , Piyachat Chuysinuan <sup>5</sup> and Pitt Supaphol 1,2,\***


**Abstract:** In daily life, people are often receiving minor cuts due to carelessness, leaving wounds on the skin. If wound healing is interrupted and the healing process does not finish, pathogens can easily enter wounds and cause infection. Liquid bandages are a fast and convenient way to help stop the bleeding of superficial wounds. Moreover, antibacterial agents in liquid bandages can promote wound restoration and fight bacteria. Herein, a poly(vinyl alcohol) (PVA) liquid bandage incorporating copper iodide nanoparticles (CuI NPs) was developed. CuI NPs were synthesized through green synthesis using gallic acid (GA) as a reducing and capping agent. The sizes of the CuI NPs, which were dependent on the concentration of GA, were 41.45, 43.51 and 49.71 nm, with the concentrations of gallic acid being 0, 2.5 mM and 5.0 mM, respectively. CuI NPs were analyzed using FTIR, XRD and SEM and tested for peroxidase-like properties and antibacterial activity. Then, PVA liquid bandages were formulated with different concentrations of stock CuI suspension. The results revealed that PVA liquid bandages incorporating 0.190% CuI synthesized with 5.0 mM of GA can kill bacteria within 24 h and have no harmful effects on human fibroblast cells.

**Keywords:** poly(vinyl alcohol) (PVA); cuprous iodide (CuI); green synthesis; liquid bandage
