**Preface**

The Hsp90 chaperone complex is responsible for the activation and maturation of a vast array of signaling proteins, which when disregulated often lead to disease. Recently, there has been a leap in our understanding of the molecular mechanisms involved in such regulation. The focus of this Special Issue is on the recent structural and biochemical advances of Hsp90 that provide insights into the mechanistic activation of Hsp90 client proteins. This special Issue brings together our current understanding of the role of the Hsp90 complex into a concise collection of articles that is aimed at researchers and scientists new to the field.

My sincere thanks go to all the authors that have contributed to this Special Issue, without whom this excellent collection of articles would not have been possible.

**Chrisostomos Prodromou**

*Editor*
