*Article* **Burnout, Depression and Sense of Coherence in Nurses during the Pandemic Crisis**

**Argyro Pachi 1, Christos Sikaras 2,3, Ioannis Ilias 4, Aspasia Panagiotou 3, Sofia Zyga 3, Maria Tsironi 3, Spyros Baras 1, Lydia Aliki Tsitrouli <sup>1</sup> and Athanasios Tselebis 1,\***


**Abstract:** During the COVID-19 pandemic, the risk to nurses' mental health has increased rapidly. The aim of the study was to investigate the prevalence of depression and burnout and to evaluate their possible association with the sense of coherence in nursing staff during the pandemic crisis. The Copenhagen Burnout Inventory questionnaire, Beck's Depression Inventory, and the Sense of Coherence questionnaire were completed by 101 male and 559 female nurses. Individual and demographic data were recorded. Regarding depression, 25.5% of respondents exhibited mild depression, 13.5% moderate depression and 7.6% severe depression. In the burnout scale, 47.1% had a pathological value. Female nurses had higher burnout (*t* test *p* < 0.01, 49.03 vs. 38.74) and depression (*t* test *p* < 0.01, 11.29 vs. 6.93) scores compared to men and lower levels in the sense of coherence (*p* < 0.05, 59.45 vs. 65.13). Regression evidenced that 43.7% of the variation in the BDI rating was explained by the CBI, while an additional 8.3% was explained by the sense of coherence. Mediation analysis indicated a partial mediation of burnout in the correlation between sense of coherence and depression. The sense of coherence acted as a negative regulator between burnout and depression.

**Keywords:** depression; sense of coherence; burnout; COVID-19; nurses
