*2.4. X-ray Powder Diffractometry*

X-ray powder diffraction (XRPD) of the samples was performed using Bruker D2 Phaser SSD 160 Diffractometer (Bruker AXS, Madison, WI) equipped with LYNXEYE scintillation detector and Cu Kα radiation (λ = 1.54184 Å) at a voltage of 30 KV and a current of 10 mA. Approximately 400 mg sample was evenly filled in a sample holder. The diffraction angle was set as 5 < 2θ < 15◦ at a rate of 2◦/min and 1 s per step with an increment of 0.1778◦ and rotated at 15 rpm to collect average diffractograms. Data was evaluated using Diffrac. EVA Suite version V4.2.1 and further processed using File Exchange 5.0 (Bruker AXS, Madison, WI, USA).

### *2.5. Differential Scanning Calorimetry*

The thermal behavior of formulation components, PM, CAD, and ASD, was assessed by differential scanning calorimetry (DSC) using Q2000 instruments (TA Instruments Co., New Castle, DE, USA). Approximately 5 mg sample was hermetically sealed in an aluminum pan. The samples were scanned over a temperature range of 10 to 250 ◦C at a rate of 10 ◦C/min to cover the melting point of the drug and excipients. Nitrogen gas was purged at a pressure of 20 psi and 50 mL/min flow rate to provide an inert atmosphere during the measurement.
