*Review* **A Comprehensive Review on Neuroimmunology: Insights from Multiple Sclerosis to Future Therapeutic Developments**

**Lucian Eva <sup>1</sup> , Horia Ples, 2,\*, Razvan-Adrian Covache-Busuioc 3,\*, Luca Andrei Glavan <sup>3</sup> , Bogdan-Gabriel Bratu <sup>3</sup> , Andrei Bordeianu <sup>3</sup> , David-Ioan Dumitrascu <sup>3</sup> , Antonio Daniel Corlatescu <sup>3</sup> and Alexandru Vlad Ciurea <sup>3</sup>**


**Abstract:** This review delves into neuroimmunology, focusing on its relevance to multiple sclerosis (MS) and potential treatment advancements. Neuroimmunology explores the intricate relationship between the immune system and the central nervous system (CNS). Understanding these mechanisms is vital for grasping the pathophysiology of diseases like MS and for devising innovative treatments. This review introduces foundational neuroimmunology concepts, emphasizing the role of immune cells, cytokines, and blood–brain barrier in CNS stability. It highlights how their dysregulation can contribute to MS and discusses genetic and environmental factors influencing MS susceptibility. Cutting-edge research methods, from omics techniques to advanced imaging, have revolutionized our understanding of MS, offering valuable diagnostic and prognostic tools. This review also touches on the intriguing gut–brain axis, examining how gut microbiota impacts neuroimmunological processes and its potential therapeutic implications. Current MS treatments, from immunomodulatory drugs to disease-modifying therapies, are discussed alongside promising experimental approaches. The potential of personalized medicine, cell-based treatments, and gene therapy in MS management is also explored. In conclusion, this review underscores neuroimmunology's significance in MS research, suggesting that a deeper understanding could pave the way for more tailored and effective treatments for MS and similar conditions. Continued research and collaboration in neuroimmunology are essential for enhancing patient outcomes.

**Keywords:** multiple sclerosis; neuroimmunology; therapeutic development
