**5. Conclusions**

Despite the fact that ceftriaxone is one of the most commonly prescribed antibiotics in health facilities, this review demonstrates that there is little information on its occurrence in the environmental samples. Due to potential consequences of their presence in the environment, it is necessary to examine and monitor their presence. The majority of studies on the strategies for the degradation or removal of ceftriaxone from various samples are based on AOPs. The most significant disadvantage of the AOP methods is their expense, which comprise the operating and maintenance costs associated with the system's needs for energy and chemical reagents. Despite the evidence that some approaches such as biological procedures cannot remove ceftriaxone, further research is needed to study the possibilities of other alternatives such as constructed wetland systems. The majority of the reviewed studies were conducted on a small scale in the laboratory under controlled environments. Alternative research is required to determine the feasibility and effectiveness of the techniques for degrading ceftriaxone in wastewater by involving the complex mixtures of contaminants and variations in weather conditions.

**Author Contributions:** Conceptualization, P.K., A.R. and K.M.; methodology, R.M.; resources, K.M. and R.M.; writing—original draft preparation, P.K.; writing—review and editing, P.K., A.R., K.M. and R.M.; supervision, A.R., K.M. and R.M. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Institutional Review Board Statement:** Not applicable.

**Informed Consent Statement:** Not applicable.

**Data Availability Statement:** Not applicable.

**Conflicts of Interest:** The authors declare no conflict of interest.

#### **References**

