*4.8. Statistical Analysis*

Statistical tests were performed on GraphPad Prism version 9.5. The normalized data from *n* = 3 independent experiments were analyzed for significance using the Brown– Forsythe and Welch one-way ANOVA. Statistical significance is set for \* *p* < 0.05, \*\* *p* ≤ 0.01, \*\*\* *p* ≤ 0.001.

**Supplementary Materials:** The following supporting information can be downloaded at: https: //www.mdpi.com/article/10.3390/ijms24119575/s1.

**Author Contributions:** P.R.S. conceptualization, methodology, investigation, formal analysis, data curation, visualization, writing—original draft; S.A.H. supervision, methodology, writing—review and editing; S.Q. resources; H.Q. resources; A.R. resources; Z.J. resources; project administration, writing—review and editing; W.Z. conceptualization, supervision, project administration, funding acquisition, resources, writing—review and editing; J.O.L. conceptualization, supervision, project administration, funding acquisition, resources, writing—review and editing. All authors have read and agreed to the published version of the manuscript.

**Funding:** The work was supported by the intramural research program of the National Center for Advancing Translational Sciences (W.Z.). This work was also supported by a grant to Z.J. and J.O.L. from the National Institutes of Health (NIH Grant: 1R21CA204836-01). Work performed at JHMI was also supported by the FAMRI grant to J.O.L. P.R.S. received support from the National Institutes of Health (NIH Grant: 5T32GM008763) and the Postdoctoral Intramural Research Training Award (IRTA) of the NIH.

**Data Availability Statement:** Data are available upon request.

**Conflicts of Interest:** Zhendong Jin is the founder and a shareholder of InnoBioPharma, LLC, Piscataway, NJ, USA, which sponsored the project, "Development of novel anticancer agents based on natural products" at the University of Iowa. All other authors declare no conflict of interest.

#### **References**


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