*4.18. Coptidis Rhizoma*

It was reported that the extract of Coptidis Rhizoma (CR) could inhibit the EMT process via the TGF-β signaling pathway [107]. It has been shown that 30% ethanol extract of Coptidis Rhizoma can inhibit cell migration and invasion via blocking E-cadherin and decreasing expression of vimentin, Snail, and ZEB2 [107]. It has a potential anti-metastatic effect and can be a candidate against cancer. The different pathways and proteins targeted by all natural products discussed in the present review are summarized in Figure 5.

**Figure 5.** Illustration of the different pathways targeted by the natural products discussed in the present review.
