*4.10. Statistical Analysis*

Differences among groups were analyzed by a one-way ANOVA followed by the Tukey test. All statistical analyses were performed using Ekuseru Toukei software ver 8.0 (Social Survey Research Information Co., Ltd., Tokyo, Japan). Differences with *p*-values of 0.05 or less were considered to be significant. All experiments were conducted with a minimum of three samples from three independent experiments, and data were expressed as means ± SD. The number of samples in each experiment is shown in the respective figure legends.

**Supplementary Materials:** The following supporting information can be downloaded at: https:// www.mdpi.com/article/10.3390/ijms24119382/s1

**Author Contributions:** The contributions of individual authors to this manuscript are as follows: Conceptualization, T.Y.; performance of experiments, K.I., M.H. and M.S.; data analysis, K.I.; writingdraft, K.I., writing, K.I. and N.V.; supervision, T.Y. All authors have read and agreed to the published version of the manuscript.

**Funding:** Funding for this study was supported by the Inoue Enryou Memorial Foundation of Toyo University.

**Institutional Review Board Statement:** Not applicable.

**Informed Consent Statement:** Not applicable.

**Data Availability Statement:** All relevant data are within the manuscript.

**Conflicts of Interest:** The authors declare no conflict of interest.
