*4.2. Cell Culture Conditions*

Lymphoblastoid cell lines (LCLs–J1209, C0401, C1504) were established and characterized by the Genethon (Evry, France). They were cultured in RPMI 1640 medium (Eurobio Scientific) supplemented with 10% decomplemented FBS (PANTM Biotech). Amino acids, vitamins, sodium pyruvate, penicillin/streptomycin and 2 mM L-glutamine were added at 1× concentrations from 100× stock solutions (all from Gibco, ThermoFisher). Four cell lines of DLBCLs, two ABC subtypes (U2932 and OCILy10) and two GCB subtypes (SUDHL4 and SUDHL6), were cultured in RPMI 1640 medium supplemented with 10% decomplemented FBS, pyruvate (1×), Penicillin/Streptomycin (1×), L-glutamine (1X) and 10 mM of HEPES buffer solution (Gibco ThermoFisher). All cell lines were maintained at 37 ◦C in a humified 5% CO2 atmosphere and were mycoplasma-free (MycoAlert Mycoplasma Detection Kit). Samples from healthy subjects were obtained from the University Hospital Center of Limoges after their informed consent.
