*2.1. Identification of Potential Genistein Targets against Human Cervical Cancer*

The targets of genistein and human cervical cancer were downloaded from the Comparative Toxicogenomics Database (CTD). In total, 28,150 protein-coding genes were related to the progression of human cervical cancer, and 2647 protein-coding genes were confirmed as the effective targets of genistein. A total of 2647 genes were identified in a Venn plot (Figure 1). Since a large number of genes were identified, we performed secondary screening using an Interaction Count (human cervical cancer target > 50; genistein target > 2). Finally, 371 genes were selected as the core targets involved in the action of genistein (data not shown), and the following analysis is based on these genes.

**Figure 1.** Venn plot of genes potentially involved in genistein's action against human cervical cancer. The purple color represents the targets of genistein, and the yellow color represents the genes related to the progression of human cervical cancer.
