**6. 3-Ketosphinganine Reductase**

3-Ketosphinganine reductase (KSR) mediates the reduction of ketosphinganine into sphinganine (Sa). In certain cancer cells (HGC27, T98G, and U87MG), 3-ketosphinganine (KSa) and its deuterated analog at C4 (d2KSa) are metabolized to produce high levels of dihydrosphingolipids [96]. Although the function of KSR has been studied in yeast and plants, the role in human pathology lacks supportive findings.
