*3.7. Network Pharmacology Study*

3.7.1. Database Mining and Identification of **10**, **11**, and NSCLC-Related Targets

The Swiss Target Prediction database (http://www.swisstargetprediction.ch), which was accessed on 14 January 2023, was utilized to gather information on the probable targets of **10** and **11**. To identify potential targets associated with NSCLC cells, various human genetic databases, such as GeneCards, TTD, OMIM, and DisGeNET, were screened. A Venn diagram illustrating the overlapping targets between **10** and **11** with respect to NSCLC can be viewed at this link (https://bioinfogp.cnb.csic.es/tools/venny/, accessed on 15 March 2023). The Venn diagram was generated using Venny 2.1.0 (Centro Nacional de Biotecnología, Madrid, Spain), https://bioinfogp.cnb.csic.es/tools/venny/, accessed on 15 March 2020.

3.7.2. Construction of Protein–Protein Interaction Network and Identification of Potential Core Targets

The overlapping targets derived from the Venn diagram were inputted into the STRING database. For STRING analysis, the organism parameter was set to Homo sapiens with the highest confidence level of 0.900. The obtained results were gathered and imported into Cytoscape v3.9.1 (The Cytoscape Consortium, San Diego, CA, USA) for

visualization and further analysis. To examine the top 10 core targets, the CytoHubba plugin was employed, using the number of degrees as the primary parameter.
