Viral Replication Complexes: Structures, Functions, Applications and Inhibitors

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HIV-1; translation; auxiliary proteins; IRES; leaky-scanning; frameshift; ribosome shunting; EV71; virus replication; ERK1; ERK2; CMV; H2O2; IE1; viral replication; antioxidants; p38-MAPK; viral replication; quasi-species; hypo-mutation; hyper-mutation; APOBEC3; cytidine deaminase; HIV; Rev; Rev response element; RRE; Crm1; nuclear export complex; DNA replication; T4 bacteriophage; replisome; HTLV-1; viral replication; viral persistence; Tax; HBZ; positive-strand RNA viruses; Flaviviridae; conformations; Dengue virus (DENV); non-structural protein 4A (NS4A); amphipathic helix; curvature sensing; peptide membrane interaction; HIV-1; Rev; nuclear export; DDX3; cap-dependent translation; IRES; +RNA viruses; replication complexes; host factors; membranes; viral replication; RNA-dependent RNA polymerase; positive-strand RNA viruses; picornaviruses; replication fidelity; enterovirus; human parechovirus; replication; antiviral; small molecules; inhibitor; viral replication complex; flavivirus; RNA-dependent RNA polymerase; RNA synthesis; 5’-RNA capping; NS5; NS3; hepatitis B virus; anti-HBV drugs; research and development; guidelines; poliovirus; RNA replication; RNA virus; membrane; membrane remodeling; electron microscopy; cell morphology; replication organelle; enterovirus; poliovirus; Sabin; oral poliovirus vaccine; vaccine-associated paralytic poliovirus; vaccine-derived poliovirus; RNA-dependent RNA polymerase; polymerase fidelity; RNA virus; poliovirus; 3CD; polyprotein; MD simulations; conformational dynamics; SAXS