Reprint

Frontiers in the Actin Cytoskeleton

Edited by
July 2020
274 pages
  • ISBN978-3-03936-565-4 (Hardback)
  • ISBN978-3-03936-566-1 (PDF)

This is a Reprint of the Special Issue Frontiers in the Actin Cytoskeleton that was published in

Biology & Life Sciences
Chemistry & Materials Science
Medicine & Pharmacology
Summary

This Special Issue of IJMS covers a broad range of cutting-edge aspects related to the organization, function, and role in disease of the actin cytoskeleton. This cellular structure is of fundamental importance for the homeostasis of every eukaryotic cell, from the simplest unicellular organism to the most complex animal cell. The actin cytoskeleton contributes to developing and maintaining cell shape and tissue integrity and is crucial for cell migration, movement of organelles, vesicle trafficking, and the completion of cell division. Elaborate structures like the sarcomere, the inner ear cell stereocilia, and the brush border microvilli are built on actin filament scaffolds. Dozens of actin-binding proteins orchestrate the dynamic remodeling of the actin cytoskeleton and integrate it with microtubules and intermediate filaments and with the cell signaling machinery. Playing such fundamental roles in a plethora of cellular processes, it comes as no surprise that defects in actin and associated proteins have been found to be implicated in pathological conditions as diverse as myopathies and neurodegenerative diseases. This Special Issue gathers 15 contributions highlighting the impressive advances made in recent years in this exciting field.

Format
  • Hardback
License and Copyright
© 2020 by the authors; CC BY-NC-ND license
Keywords
cyclase-associated proteins; oligomerization; coiled coils; actin severing; actin depolymerization; α-barrels; dysferlin; actin; C2 domains; annexin A2; dysferlinopathy; actin cytoskeleton; chlamydia; bacterial pathogenesis; exosome; microvesicle; microfilament; integrins; bone remodeling; myosins; actin-related protein; proteomics; extracellular vesicles; rootlet; actin; stereocilia; hair cell; AtFH13; AtFH14; At5g58160; At1g31810; FH2 domain; class II formin; confocal laser scanning microscopy; PTEN-like domain; actin; Arp2/3 complex; cAMP; coronin 1; integrin β2; platelets; thrombin; collagen; prostacyclin; cell mechanics; F-actin; microtubules; image recognition-based cytoskeleton quantification; AFM; synaptopathy; actin cytoskeleton; actin-binding proteins; amyloid; synaptic plasticity; Dictyostelium; coronin A; interactome analysis; Actin; ezrin; moesin; actin; leukocytes; polarization; immune synapse; Arf GTPases; actin cytoskeleton; wave regulatory complex; phagocytosis; macrophages; host–pathogen interplay; long-range allostery; actin; actin-binding protein; cofilin; cooperativity; drebrin; filamin; fimbrin; gelsolin; myosin; tropomyosin; actin; mutation; polymerization; myosin; actin cytoskeleton; myosin; C. elegans embryo; asymmetric cell division; n/a

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