Reprint

The Role of Selenium in Health and Disease

Edited by
July 2020
170 pages
  • ISBN978-3-03936-146-5 (Hardback)
  • ISBN978-3-03936-147-2 (PDF)

This is a Reprint of the Special Issue The Role of Selenium in Health and Disease that was published in

Medicine & Pharmacology
Public Health & Healthcare
Summary

This book contains ten articles covering recent advances in our understanding of the relationship between the essential micronutrient selenium and human health and disease. Taken together, these articles strengthen the evidence showing that selenium, as a constituent of selenoproteins, is central to biological stress responses and mechanisms commonly altered in most complex disorders. Relevant to public health concerns, this book also emphasizes the U-shaped dose-response relationship between selenium concentration and disease risk across diverse populations from Europe [articles 2,3,6], the Middle East and North Africa [9], and Taiwan [5]. This highlights the importance of personalized nutrition strategies targeted at individuals with increased risk of disease and low selenium intake. The mechanisms by which selenium status, selenoprotein expression, and inherited genetic variations in the selenium pathway interact to affect molecular pathways involved in disease development are explored in human cohorts [2,3,5-7], and in animal [4] and in vitro models [8]. Furthermore, some reports identified novel potential biomarkers of disease risk and prognosis within the selenium pathway that could further our understanding of many chronic diseases [2,3]. Overall, this book broadens our understanding  of the role of selenium in chronic diseases, and provides new directions for future preventative approaches.

Format
  • Hardback
License and Copyright
© 2020 by the authors; CC BY-NC-ND license
Keywords
selenium; selenoprotein F; thiol–disulfide oxidoreductase; endoplasmic reticulum stress; protein folding quality control; single nucleotide polymorphisms; selenium (Se), selenoproteins; gene expression; selenium status; selenoprotein P; colorectal neoplasm; colorectal cancer; colorectal adenoma; biomarkers; cancer risk; selenium; metabolic syndrome; obesity; insulin resistance; lipid; selenium; selenium status; selenoprotein gene variation; selenium pathway; colorectal neoplasms; selenoprotein P; prospective cohort; colorectal cancer risk; genetic epidemiology; biomarkers; selenium; chronic diseases; Middle East; North Africa; selenium; selenoprotein; selenized lipids; Selol; Gpx1; Gpx4; Txnrd1; Txnrd2; ICP-MS; agrp; hypothalamus; leptin; scly; selenium; selenoprotein; thermogenesis; type 2 diabetes; Selenoprotein-P; selenium; cardiovascular disease; prevention; supplementation; trace element; biomarker; selenoprotein; metabolism; redox regulation; prediction; reactive oxygen species; glutathione peroxidases; thioredoxin reductases; influenza virus; hepatitis C virus; coxsackie virus; human immunodeficiency virus; molluscum contagiosum virus; viral selenoproteins; immunity; n/a