Reprint
Adipose-Derived Stromal/Stem Cells
Edited by
October 2020
286 pages
- ISBN978-3-03943-282-0 (Hardback)
- ISBN978-3-03943-283-7 (PDF)
This is a Reprint of the Special Issue Adipose-Derived Stromal/Stem Cells that was published in
Biology & Life Sciences
Medicine & Pharmacology
Summary
Adipose tissue is a rich, ubiquitous, and easily accessible source for multipotent mesenchymal stromal/stem cells (MSCs), so-called adipose-derived stromal/stem cells (ASCs). Primary isolated ASCs are a heterogeneous preparation consisting of several subpopulations of stromal/stem and precursor cells. Donor-specific differences in ASC isolations and the lack of culture standardization hinder the comparison of results from different studies. Nevertheless, ASCs are already being used in different in vivo models and clinical trials to investigate their ability to improve tissue and organ regeneration. Many questions concerning their counterparts and biology in situ, their differentiation potential in vitro and in vivo, and the mechanisms of regeneration (paracrine effects, including regeneration-promoting factors and extracellular vesicles, differentiation, and immunomodulation) are not completely understood or remain unanswered. This Special Issue covers research articles investigating various adipose tissues as a source for ASC isolation, specific cultures methods to enhance proliferation or viability, and the differentiation capacity. Furthermore, other studies highlight aspects of various diseases, the immunosuppressive potential of ASCs and their derivates, or the in vivo tracking of transplanted ASCs. This edition is complemented by a review that summarizes the current knowledge of spheroid culture system methods and applications for mesenchymal stem cells.
Format
- Hardback
License and Copyright
© 2020 by the authors; CC BY-NC-ND license
Keywords
lipomas; adipose tissue; stem cells; adipogenesis; osteogenesis; mesenchymal stem cells; T-cells; conditioned medium; extracellular vesicles; TLR; INF-γ; adipose-derived stromal cells; equine metabolic syndrome; metformin; adipose-derived stem cells; adipocytes; differentiation; collagen I; adiponectin; integrins; discoidin domain-containing receptor; ageing; subcutaneous fat; adipose tissue-derived mesenchymal stromal/stem cells (ASCs); cell differentiation; volatile organic compounds; metabolic monitoring; adipogenesis; adipose-derived stromal/stem cells; chondrogenesis; colony forming unit-fibroblast; fetal bovine serum; human platelet lysate; mesenchymal stem cell; osteogenesis; regenerative medicine; human adipose-derived stem cells; human platelet lysate; stem cell proliferation; fetal bovine serum; signaling pathway; adipose-derived mesenchymal stem cells; differentiation; migration; secretion; primary cilium; sonic hedgehog signaling; mesenchymal stromal/stem cells; perirenal; adipose tissue; fat; characterization; stimulation; lipopolysaccharide; cytokines; cytomegalovirus; angiogenesis; adipose derived mesenchymal cells; Histogel; 3D cell culture; spheroid culture; biomaterials; adipose-derived mesenchymal stem cells; phenotype; secretory potential; ankylosing spondylitis; systemic lupus erythematosus; systemic sclerosis; mesenchymal stromal cells; adipose tissue; breast cancer; tumor microenvironment; perineural invasion; adipose derived stem cells; valproic acid; protein interactions; MAPK pathway; JAK/STAT pathway; mesenchymal stromal cell; differentiation; tissue of origin; prolonged culture; epigenetic memory; tracking; mesenchymal stromal/stem cells; bio imaging; bioluminescence; qRT-PCR; Ataxia telangiectasia; Atm; n/a