Reprint

Animal Modeling in Cancer

Edited by
August 2021
274 pages
  • ISBN978-3-0365-1276-1 (Hardback)
  • ISBN978-3-0365-1277-8 (PDF)

This is a Reprint of the Special Issue Animal Modeling in Cancer that was published in

Biology & Life Sciences
Summary

Dear Readers,

Understanding the pathological mechanisms involved in human diseases and their possible treatment has been historically based on comparative analysis of diverse animal species that share a similar genetic, physiological and behavioural composition. The ancient Greeks were the first to use animals as models for anatomy and physiology, and this was consequently adopted by other cultures and led to important discoveries.

In recent years, there have been many efforts to understand and fight cancer through new revolutionary personalized treatments and wider screenings that help diagnose and treat cancer. A fundamental part of this effort is to develop suitable cancer animal models that simulate the different disease variants and their progression. Ranging from tumor-derived xenografts to genetically engineered models, a wide variety of systems are applied for this purpose, and many technological breakthroughs are changing the way cancer is studied and analyzed.

In this Special Issue, we collected a set of research articles and reviews that focus on the generation of cancer animal models that are used for understanding the disease and contribute to designing and testing new drugs for cancer prevention or treatment.

Vladimir KorinekCollection Editor

Format
  • Hardback
License and Copyright
© 2022 by the authors; CC BY-NC-ND license
Keywords
soy; isoflavones; mammary tumor prevention; rodent models; chemical carcinogens; transgenic mice; Zebrafish; Drosophila; rats; mice; NPM-1; FLT3 ITD; ETO-1; IDH1/2; neural stem cells; brain and nervous system cancers; neurogenic niches; radiotherapy; sparing of neurogenic regions; carcinoma; consensus molecular subtypes; intestine; oncogenes; signaling cascades; tumor suppressors; tumorigenesis; MPN (myeloproliferative neoplasms); zebrafish; mice; iPSCs; JAK2; MPL; CALR; thrombosis; ubiquitin–proteasome system; cancer; mouse model; gene inactivation; colorectal cancer; mouse models; microbiota; antitumor immunity; melanoma; mutation; genetics; animal model; swine; MeLiM; progression; spontaneous regression; devitalization; metaplasia; Cdx; cancer; animal models; zebrafish; epigenetics; xenotransplantation; drug screen; pre-clinical cancer model; cancer; mouse models; non-mouse models; gene editing; stem cells; solid tumors; hematologic malignancies