Keywordsheteroaromatics; C-H bond functionalization; oxidative cyclization; cross-coupling; amination; triazoles; palladium; carbene ligands; heterocycles; nitrogen-containing heterocycles; synthesis; antiviral agents; viruses; COVID-19; inhibition; COVID-19; Mpro inhibitors; drug design and synthesis; structure-activity relationships (SAR); s-tetrazine; 4H-1,2,4-triazole; pinner reaction; synthesis; 1,2,3-triazole; fused 1,2,3-triazole; 1,2,3-triazolo[4,5-b]pyrazine; 1,2,3-triazolo[4,5-c]pyridazine; 1,2,3-triazolo[4,5-d]pyridazine; 1,2,3-triazolo[1,5-a]pyrazine; 1,2,3-triazolo[1,5-b]pyridazine; triazolopyrazine; triazolopyridazine; practical applications; spiro π-conjugated compound; chiral compound; thiophene; furan; pyrrole; nucleophilic aromatic substitution; circular dichroism; circularly polarized luminescence; pyridines; 1,3,4-thiadiazoles; 1,3-thiazoles; hydrazonoyl halides; molecular docking; anticancer activity; 1,3,4-oxadiazoles; organic ligands; heterocycles; substitution; diisopropyl iminodiacetate; pyrimidine; benzimidazole; aza-Diels–Alder reaction; Povarov reaction; oxidation; fluorescence; aggregation-induced emission; mechanochromic properties; heterocycle; natural product; nicotinic acid; thiophene; fungicidal activity; 4-pyrone; DMF-DMA; enamination; cycloaddition; merocyanine; 1,6-conjugate addition; solvatochromism; fluorophore; acetylcoumarin; hydrazonoyl halides; thiazoles; molecular docking; VEGFR-2; polyfluoroflavones; 1H-1,2,4-triazole; imidazole; nucleophilic aromatic substitution; regioselectivity; azolyl-substituted flavones; photoluminescence; 4-pyridone; oxazinone; ring-opening; benzimidazole; aldehyde-lactol tautomerism; ammonium acetate; diazirine; heteroaromatics; medicinal chemistry; photoaffinity labeling; metathesis; heteroaromatics; carboaromatics; 4,5-dihydro-5-oxo-pyrazolo[1,5-a]thieno[2,3-c]pyrimidines; novel scaffold; thiophene; molecular dynamic studies; proximity frequencies (PF); GABAA receptor subtype; GABAA receptor ligands; antibacterial; anticancer; antifibrotic; antifungal; antimicrobial; antiviral; appel salt; 1,2,3-dithiazole; disulfide bridge; herbicidal; chalcone; heteroaromatic; hybrid chalcone; n/a