Reprint

Intervertebral Disc Regeneration II

Edited by
July 2023
136 pages
  • ISBN978-3-0365-8198-9 (Hardback)
  • ISBN978-3-0365-8199-6 (PDF)

This is a Reprint of the Special Issue Intervertebral Disc Regeneration II that was published in

Biology & Life Sciences
Chemistry & Materials Science
Computer Science & Mathematics
Engineering
Environmental & Earth Sciences
Physical Sciences
Summary

This second volume on the subject of intervertebral disc (IVD) regeneration ranges from in vitro IVD cell culture studies on cytokines, such as TGFβ3, GDF5, GDF6, ANG1, and ANG2, to diffuse idiopathic skeletal hyperostosis (DISH) to novel advances in the diagnosis of painful discs in reports using natural language processing (NLP). This diverse issue consists of seven articles that provide a comprehensive overview of recently applied research insights. Three original articles focus on the effects of cytokines in primary cell culture. Then, two original articles report on transcriptomics data, i.e., single-cell RNA-sequencing data of in vivo rat animal models of IVD degeneration, and human prime PCR data comparing trauma versus DISH-IVDs. One original article addresses the correct diagnosis of lumbosacral transitional vertebrae (LSTV) in scoliotic patients, and another original article addresses the usage of NLP to improve the diagnosis of painful IVDs. The Special Issue is concluded with a review on the importance of the relatively recent “hot topic” of extracellular vesicles (EVs) for regenerative purposes in IVDs.

 

Format
  • Hardback
License and Copyright
© 2022 by the authors; CC BY-NC-ND license
Keywords
tissue engineering; intervertebral disc; progenitor cells; GDF5; GDF6; TGFβ3; single-cell RNA-seq; nucleus pulposus progenitor cells (NPPC); diffuse idiopathic hyperostosis; extracellular vesicles; rat tail model; scoliosis; natural language processing

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