Reprint

Frontiers in Nucleic Acid Chemistry —in Memory of Professor Enrique Pedroso for His Outstanding Contributions to Nucleic Acid Chemistry

Edited by
January 2024
200 pages
  • ISBN978-3-0365-9898-7 (Hardback)
  • ISBN978-3-0365-9897-0 (PDF)

This is a Reprint of the Special Issue Frontiers in Nucleic Acid Chemistry—in Memory of Professor Enrique Pedroso for His Outstanding Contributions to Nucleic Acid Chemistry that was published in

Chemistry & Materials Science
Medicine & Pharmacology
Summary

This reprint is dedicated to the memory of Enrique Pedroso, Professor Emeritus of Organic Chemistry at University of Barcelona, who passed away at the age of 72 on September 2020. Professor Enrique Pedroso has been one of the pioneers of Nucleic Acids Chemistry in Spain, significantly contributing to the development of this highly interdisciplinary field which combines organic chemistry, biochemistry, pharmacology, materials chemistry, and biophysics. His major research achievements were accomplished in the synthesis of modified oligonucleotides and especially conjugates and cyclic oligonucleotides, as well as their analogues, which opened up new avenues in the search for novel applications of oligonucleotides.This reprint comprises a collection of research or review articles prepared by international experts in Nucleic Acids, including nucleoside and oligonucleotide synthesis, nucleic acids structural studies, DNA repair, and biophysical characterization of DNA-targeting ligands, especially G-quadruplex binding drugs.

Format
  • Hardback
License and Copyright
© 2022 by the authors; CC BY-NC-ND license
Keywords
Pu22; G-quadruplex; c-myc; phytochemicals; circular dichroism; in silico simulations; molecular docking; CD prediction; G-quadruplex; N-acetylgalactosamine; antisense; oligonucleotide conjugates; asialoglycoprotein receptor; luciferase gene; gapmers; 2′,3′-dideoxynucleosides; 2′,3′-didehydro-2′,3′-dideoxynucleosides; synthesis; zalcitabine (ddC); didanosine (ddI); stavudine (d4T); G-quadruplex; PARP1 promoter; stabilizing ligand; NMR; circular dichroism; fluorescence; molecular modeling; DNA structure; RNA structure; quadruplex; tetrad; intrinsic fluorescence; DNA; aptamer; binding; modified nucleic acids; DNA polymerases; nucleoside triphosphates; primer extension reactions; SELEX; antimicrobial resistance; n/a; oligonucleotides; DNA recognition; chromosomes; DNA; pyrene; fluorescence; FISH; karyotyping; SNP; strand invasion; DNA quadruplex; duplex-quadruplex equilibrium; base excision repair; pyridostatin; glycosylase; telomere; 5′-functionalization; small molecules; conjugates of oligonucleotides; solid-phase synthesis; pH-sensitive phosphoramidate linkage; siRNA; phosphorodiamidate morpholinos (PMO); phosphoroamidate morpholinos (MO); thiophosphoramidate morpholinos (TMO); phosphoramidites; amyotrophic lateral sclerosis; frontotemporal dementia; C9orf72; GGGGCC; G4; n/a