Reprint

Molecular Characterization of Gram-Negative Bacteria: Antimicrobial Resistance, Virulence and Epidemiology

Edited by
July 2024
204 pages
  • ISBN978-3-7258-1418-3 (Hardback)
  • ISBN978-3-7258-1417-6 (PDF)

This is a Reprint of the Special Issue Molecular Characterization of Gram-Negative Bacteria: Antimicrobial Resistance, Virulence and Epidemiology that was published in

Biology & Life Sciences
Medicine & Pharmacology
Summary

Multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) Gram-negative bacteria constitute a huge public health problem. Among them, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii are the main bacteria contributing to increased rates of antimicrobial resistance. Infections caused by these bacteria can have a negative impact on the financial costs and outcomes of patient hospitalization. The increased consumption of antimicrobials and the poor implementation of infection control measures in the hospital setting are the two main causative factors for their emergence. Deep knowledge of the virulent factors that these bacteria produce could provide useful information regarding their spread.

The main problem concerning infections caused by these bacteria is that treatment options are extremely limited, as there has been a poor launch of novel antimicrobials over the last few years. The molecular epidemiology of infections caused by Gram-negative bacteria is significant as it can determine which of these few new antimicrobial agents could be effective for their treatment. This Special Issue collects manuscript submissions that expand our knowledge of antimicrobial resistance in Gram-negative bacteria.

Format
  • Hardback
License and Copyright
© 2024 by the authors; CC BY-NC-ND license
Keywords
Klebsiella pneumoniae; multidrug-resistant; extensively drug-resistant; colistin; carbapenem; quantitative proteomics; tandem mass tag; Acinetobacter baumannii; secretion systems; pathogenicity; antibiotic resistance; Klebsiella pneumoniae; multidrug resistance; transmission; Sudan; carbapenem-resistant Klebsiella pneumoniae; molecular epidemiology; antimicrobial agents; virulence factors; phloroglucinol; polyketide; DAPG; phlD; Ramachandran plot; PMDB; duck–fish polyculture farm; Escherichia coli; antibiotic resistance; blaCTX-M-55; F18:A-:B1; transmission; carbapenem-resistant Klebsiella pneumoniae; whole genome sequencing; core genome single-nucleotide polymorphism analysis; molecular epidemiology; antimicrobial resistance; antibiotics synergy; carbapenemase; NDM-beta-lactamase; Klebsiella pneumoniae; carbapenemases; NDM; plasmid; Proteus mirabilis; Morganella morganii; carbapenem-resistant Acinetobacter baumannii; cefiderocol; sulbactam-durlobactam; antimicrobial susceptibility; mechanisms of resistance; antimicrobial therapy; oxygen concentration; antimicrobial resistance; biofilm; pyocyanin; pyoverdine; motility; proteases; colistin resistance; mechanisms; mgrB; population analysis profiling; whole-genome sequencing; n/a