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Strong Bones and Healthy Joints: Insights into the Musculoskeletal System...
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Strong Bones and Healthy Joints: Insights into the Musculoskeletal System Health of Farm, Companion, and Wild Animals

A special issue of Animals (ISSN 2076-2615).

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 5713

Special Issue Editors

Dr. Siemowit Muszyński

E-Mail Website
Guest Editor
Department of Biophysics, University of Life Sciences in Lublin, 20-950 Lublin, Poland
Interests: nutrition; muscoseletal system; bone metabolism and development; bone loss; bone and tendon mechanical properties
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Ewa Tomaszewska

E-Mail Website
Guest Editor
Department of Animal Physiology, University of Life Sciences in Lublin, 20-950 Lublin, Poland
Interests: prenatal programming; postnatal development; physiology; nutrition; probiotics; glucocorticoids; heavy metals; toxicology; bone metabolism and development; bone and tendon mechanical properties; gut structure; gut-bone axis; skin in fur animals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The main tasks of the skeletal system, which together with the muscle and ligament system co-create the locomotor system, include providing rigidity to particular elements of the body, which enables appropriate mobility of the animal, countering gravitational force, and protecting organs that are important to the body. Bones, tendons, and ligaments interact with each other and together determine the mechanical, kinetic, and metabolic properties of the locomotor system. Mechanical dysfunctions of musculoskeletal system have a considerable welfare impact and are responsible for significant financial implications and losses in both farm and companion animals; they also reduce the survival rate of wild animals. Connective tissue homeostasis fluctuates with age and is regulated by many factors, including nutrition, rearing conditions, and hormonal factors, and can be disordered by exposure to toxins or toxic elements. This Special Issue seeks to report recent original research findings and reviews focused on skeletal system development and biomechanics; bone biology, physiology, structure, and homeostasis; systemic disorders related to bone loss; as well as any aspect of the diagnostic and treatment pathways of bone-, joint-, and tendon-associated problems in animals. Studies on laboratory animal models are also welcome. You are invited to submit your work on these topics.

Dr. Siemowit Muszyński
Prof. Dr. Ewa Tomaszewska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone quality
  • bone biology
  • bone homeostasis
  • cartilage
  • tendon
  • joint
  • bone fracture
  • tendon rupture
  • joints disorders
  • welfare
  • nutrition

Published Papers (2 papers)

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Research

15 pages, 1208 KiB  
Article
The Influence of Nesfatin-1 on Bone Metabolism Markers Concentration, Densitometric, Tomographic and Mechanical Parameters of Skeletal System of Rats in the Conditions of Established Osteopenia
by Grzegorz Tymicki, Iwona Puzio, Marta Pawłowska-Olszewska, Marek Bieńko and Radosław Piotr Radzki
Animals 2022, 12(5), 654; https://doi.org/10.3390/ani12050654 - 4 Mar 2022
Cited by 3 | Viewed by 1867
Abstract
Our study aimed to evaluate the impact of nesfatin-1 administration on bone metabolism and properties in established osteopenia in ovariectomized female rats. In total, 21 female Wistar rats were assigned to two groups: sham-operated (SHAM, n = 7) and ovariectomized (OVA, n = [...] Read more.
Our study aimed to evaluate the impact of nesfatin-1 administration on bone metabolism and properties in established osteopenia in ovariectomized female rats. In total, 21 female Wistar rats were assigned to two groups: sham-operated (SHAM, n = 7) and ovariectomized (OVA, n = 14). After 12 weeks of osteopenia induction in the OVA females, the animals were given i.p. physiological saline (OVA, n = 7) or 2 µg/kg body weight of nesfatin-1(NES, n = 7) for the next 8 weeks. The SHAM animals received physiological saline at the same time. Final body weight, total bone mineral density and content of the skeleton were estimated. Then, isolated femora and tibias were subjected to densitometric, tomographic, and mechanical tests. Bone metabolism markers, i.e., osteocalcin, bone specific alkaline phosphatase (bALP), and crosslinked N-terminal telopeptide of type I collagen (NTx) were determined in serum using an ELISA kit. Ovariectomy led to negative changes in bone metabolism associated with increased resorption, thus diminishing the densitometric, tomographic, and mechanical parameters. In turn, the administration of nesfatin-1 led to an increase in the value of the majority of the tested parameters of bones. The lowest bALP concentration and the highest NTx concentration were found in the OVA females. The bALP concentration was significantly higher after nesfatin-1 administration in comparison to the OVA rats. In conclusion, the results indicate that nesfatin-1 treatment limits bone loss, preserves bone architecture, and increases bone strength in condition of established osteopenia. Full article
(This article belongs to the Special Issue Strong Bones and Healthy Joints: Insights into the Musculoskeletal System Health of Farm, Companion, and Wild Animals)
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15 pages, 1788 KiB  
Article
Does PRGF Work? A Prospective Clinical Study in Dogs with A Novel Polylactic Acid Scaffold Injected with PRGF Using the Modified Maquet Technique
by Victoria Valiño-Cultelli, Óscar Varela-López and Antonio González-Cantalapiedra
Animals 2021, 11(8), 2404; https://doi.org/10.3390/ani11082404 - 14 Aug 2021
Cited by 3 | Viewed by 2592
Abstract
Tibial tuberosity advancement is a surgical technique to restore the dynamical stability in the knee by advancing the insertion of the patellar ligament, for which it is necessary to advance the tibial crest, being maintained in the desired position usually by a cage [...] Read more.
Tibial tuberosity advancement is a surgical technique to restore the dynamical stability in the knee by advancing the insertion of the patellar ligament, for which it is necessary to advance the tibial crest, being maintained in the desired position usually by a cage and metallic implants. The purpose of this study was to replace the cage with a polylactic acid biodegradable scaffold designed for each patient by 3D printing, inserting platelet-rich in growth factors (PRGF) to demonstrate its osteoinductive properties. To this end, we used the modified Maquet technique to reduce the amount of metal to a minimum. Fifty-three dogs finished the study. The control and PRGF groups did not present any statistically significant differences in terms of ossification degree (p > 0.001) but they demonstrated satisfactory ossification compared to previous publications, although in the PRGF group three of the scaffolds suffered complete reabsorption. The PRGF and control groups did not show any statistically significant differences in terms of lameness degree (p > 0.001). However, the PRGF group showed at the first control some analgesic and anti-inflammatory properties but they were not enough for reducing the functional recovery time in a significant way. The PRGF group did not show any complications or negative results associated with their use. Full article
(This article belongs to the Special Issue Strong Bones and Healthy Joints: Insights into the Musculoskeletal System Health of Farm, Companion, and Wild Animals)
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