Biological Evaluation of Drugs
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".
Deadline for manuscript submissions: 20 May 2025 | Viewed by 376
Special Issue Editor
Interests: clinical pharmacology; surgical oncology; immune-oncology; drug targeting; drug safety; breast cancer; endocrine cancer; colorectal cancer; familial cancer
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Special Issue Information
Dear Colleagues,
The biological evaluation of drugs is important for the study of pharmacological activity, potency and toxicity. These methods are considered to be less precise, more time-consuming and more expensive. Biological evaluation is especially needed for the biological evaluation of crude drugs, i.e., any naturally occurring, unrefined substance derived from organic or inorganic sources such as plant, animal, bacteria, organs or whole organisms.
Bioassays should be as simple as possible, and attempts should be made to have access to a large number of different tests so that many biological properties can be screened. The bioassay methods are of three types: toxic, symptomatic and tissue or organ methods. Different animals are used in the toxic and symptomatic methods, and isolated organs or tissue are used in the third method. These assays are conducted by determining the amount of drug of known potency required to produce a definite effect on suitable test animals or organs under standard conditions. Reference standards are used in certain bioassay procedures to minimize errors. Toxicity studies aim to evaluate the safety of potential drug candidates. They are performed in suitable animal models and validated procedures are used in order to decide the lethal dose and effective dose.
Dr. Eugenia Yiannakopoulou
Guest Editor
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Keywords
- biological evaluation and crude drugs
- biological evaluation and pharmacological activity
- biological evaluation and toxicity
- biological evaluation and potency
- animal models in biological evaluation
- bioassays and error minimization
- tissue or organ bioassays in drug evaluation
- biological evaluation and vaccines
- biological evaluation and antimicrobials
- biological evaluation of carcinogenic potential
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