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Biomedicines
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Toxicity and Biocompatibility: The Janus Faces of Biomaterial Interactions with...
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Toxicity and Biocompatibility: The Janus Faces of Biomaterial Interactions with Life

A special issue of Biomedicines (ISSN 2227-9059).

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 2651

Special Issue Editors

Prof. Dr. Bertrand Rihn

E-Mail Website
Guest Editor
Institut Jean Lamour, UMR CNRS 7198, Université de Lorraine, CNRS, IJL, F-54000 Nancy, France
Interests: nanomaterial; transcriptomic and proteomic analysis; biopersistency; transition metals
Dr. Christophe Rouillon

E-Mail Website
Guest Editor
Biomedical Center (BMZ), Building 13, University of Bonn, Venusberg Campus 1, 53127 Bonn, Germany
Interests: informational events; CRISPR/Cas systems; bacteria; archaea

Special Issue Information

Dear Colleagues,

Life has always had to deal with the inert world. Cells are frequently exposed to a hostile and toxic environment. Molecular machinery at the cell, organ, or organism level is adapted to absorb, distribute, metabolize, and eliminate xenobiotics whether toxic or in any other way harmful to life. What are the strategies of (i) cells in tissues, (ii) cells specialized in detoxification, and (iii) the bacteria surrounding them for adapting to materials built with transition metals for implant purposes? What are the molecular mechanisms involved at the interface of living cells and new alloys intended to be implanted in human organs, bones, or soft tissues? How should their surface be to avoid any immunotoxicity or immune reaction? How is it possible to avoid biofilm formation and prosthesis rejection due to bacteria proliferation? It is well known today that bacteria may play a crucial role in prosthesis rejection as they may colonize better implant surfaces than eukaryotes cells. Is it possible to define at the molecular level of cells what the best surface treatments are for a successful implantation of new prosthetic alloys? Every answer to those stimulating questions is welcomed in this Special Issue, especially if based on holistic approaches such as proteomics or transcriptomics analysis.

Prof. Dr. Bertrand Rihn
Dr. Christophe Rouillon
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • transition metal
  • implant
  • immunotoxicity
  • osseointegration
  • macrophage
  • alloy

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Published Papers (1 paper)

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Research

16 pages, 4982 KiB  
Article
In Vitro Molecular Study of Titanium-Niobium Alloy Biocompatibility
by Laëtitia Chézeau, Alex Tchinda, Gaël Pierson, Pierre Bravetti, Luc Ferrari, Olivier Joubert, Mohamed Zaiou and Bertrand H. Rihn
Biomedicines 2022, 10(8), 1898; https://doi.org/10.3390/biomedicines10081898 - 5 Aug 2022
Cited by 4 | Viewed by 2263
Abstract
Titanium dental implants have common clinical applications due to their biocompatibility, biophysical and biochemical characteristics. Although current titanium is thought to be safe and beneficial for patients, there are several indications that it may release toxic metal ions or metal nanoparticles from its [...] Read more.
Titanium dental implants have common clinical applications due to their biocompatibility, biophysical and biochemical characteristics. Although current titanium is thought to be safe and beneficial for patients, there are several indications that it may release toxic metal ions or metal nanoparticles from its alloys into the surrounding environment, which could lead to clinically relevant complications including toxic reactions as well as immune dysfunctions. Hence, an adequate selection and testing of medical biomaterial with outstanding properties are warranted. This study was designed to explore the biocompatibility of smooth titanium-niobium alloy (S_TiNb) versus smooth titanium commercially pure (S_TiCp)—a reference in implantology. All experiments were performed in vitro using human osteoblast-like SaOs-2 and monocyte THP-1 cell lines as models. Cell adhesion and growth morphology were determined by scanning electron microscopy, while cell viability was evaluated using WST-1 assay. Because niobate anions or niobium nanoparticles can be released from implants during biomaterial-cell interaction, potential immunotoxicity of potassium niobate (KNbO3) salt was evaluated by examining both metabolic activity and transcriptomic profiling of treated THP-1 monocytes. The main findings of this study are that S_TiCp and S_TiNb discs do not show an impact on the proliferation and viability of SaOs-2 cells compared to polystyrene surfaces, whereas a significant decrease in THP-1 cells’ viability and metabolic activity was observed in the presence of S_TiNb discs compared to the control group. However, no significant changes were found neither at the metabolic activity nor at the transcriptomic level of THP-1 monocytes exposed to KNbO3 salt, suggesting that niobium has no effect on the immune system. Overall, these data imply a possible toxicity of S_TiNb discs toward THP-1 cells, which may not be directly related to niobium but perhaps to the manufacturing process of titanium-niobium alloy. Thus, this limitation must be overcome to make titanium alloy an excellent material for medical applications. Full article
(This article belongs to the Special Issue Toxicity and Biocompatibility: The Janus Faces of Biomaterial Interactions with Life)
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