Immunotherapy and Transplantation in the Era of Transplant Oncology
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Transplant Oncology".
Deadline for manuscript submissions: 31 August 2024 | Viewed by 20317
Special Issue Editors
2. Cockrell Center for Advanced Therapeutics (CCAT) – Phase I Program, Houston Methodist Research Institute, Houston, TX 77030, USA
3. Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA
Interests: pancreatic cancer; liver cancer; cholangiocarcinoma; biliary cancer; transplant oncology; phase I drugs; targeted therapy; drug discovery; immunotherapy
Special Issues, Collections and Topics in MDPI journals
2.Director of Clinical Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Interests: onco-nephrology; transplant oncology; immunotherapy; immunotherapy toxicity; renal transplant
2. Houston Methodist Research Institute, Houston, TX 77030, USA
Interests: transplant oncology; liver cancer; cholangiocarcinoma; targeted therapy; immunotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Immune-checkpoint inhibitor (ICPI) therapies have shown excellent responses with tolerable side effects in the treatment of different cancers. However, our knowledge and experience in the use of immunotherapy in solid organ transplant recipients and candidates are limited.
The use of immunotherapy in liver pre-transplant patients as bridging therapy, and as palliative therapy in post-transplant patients to treat cancer recurrence or second primary cancer, is an area of unmet need. Transplant patients have been excluded from ICPI clinical trials due to concern for autograft rejection. In the last five years, retrospective studies and limited prospective trials have shown the possibility of using ICPIs in this patient population. This field of transplant oncology is currently being investigated. Our Special Issue will highlight the current state of the utilization of ICPI therapies in pre- and post-liver and other solid organ transplants, and will discuss the assessment of safety and response biomarkers.
Dr. Maen Abdelrahim
Dr. Ala Abudayyeh
Dr. Abdullah Esmail
Guest Editors
Manuscript Submission Information
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Keywords
- transplant oncology
- liver transplantation
- solid organ transplantation, hepatocellular carcinoma
- immunotherapy
- immune-checkpoint inhibitors
- CTLA-4 inhibitors
- PD-1 inhibitors
- allograft rejection
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