Axonal Transport: Mechanisms, Disorders, and Therapeutic Approaches
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 30 June 2025 | Viewed by 154
Special Issue Editors
Interests: neurodegenerative mechanisms; autophagy; mitochondria; axonal transport
Interests: cell-cell communications; autophagy; exosomes; autism spectrum disorders (ASDs); neural circuits
Special Issue Information
Dear Colleagues,
Axonal transport is a critical cellular process responsible for the movement of organelles, proteins, and other molecules along the axons of neurons. This process is essential for maintaining neuronal function and survival. Disruptions in axonal transport are implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and peripheral neuropathies. This Special Issue aims to bring together cutting-edge research on the molecular mechanisms of axonal transport, its role in neurodegenerative diseases, and potential therapeutic strategies to ameliorate transport-related dysfunctions.
This Special Issue will cover a broad range of topics related to axonal transport, including, but not limited to, the following:
- Molecular mechanisms of anterograde and retrograde transport;
- Role of motor proteins in axonal transport;
- Regulation of axonal transport by signaling pathways;
- Cargo selection, sorting, and delivery mechanisms;
- Impact of axonal transport dysfunction on neurodegenerative diseases;
- Axonal transport in development and aging;
- Therapeutic approaches to targeting axonal transport defects;
- New technological achievements in studying axonal transport;
- Animal models and clinical studies of axonal transport disorders.
Dr. Yuxiang Xie
Dr. Jingqi Yan
Guest Editors
Manuscript Submission Information
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Keywords
- axonal transport
- motor proteins
- autophagy–lysosome pathway
- neurodegenerative diseases
- therapeutic strategies
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