New Developments in Rheumatoid Arthritis
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 481
Special Issue Editors
Interests: rheumatoid arthritis; oncogenes; autoimmunity
Special Issue Information
Dear Colleagues,
Rheumatoid arthritis is a canonical autoimmune disease characterized by chronic inflammation in the joints and causes severe functional sequelae if untreated. The success of cytokine-targeting treatments has improved our understanding of the molecular pathways in RA and shifted the treatment goal from the palliative management of late consequences to early remission and the prevention of RA-related morbidity, but even more remains to be explored. A deeper understanding of RA pathogenesis is critical to solve the unmet needs.
Despite all that we have learned, many questions still remain unanswered. For example, what is the order of priority of cellular events in RA, and how can we trace these events in patients? How does autoimmunity transform into arthritis? How do the molecular events change during different clinical stages of the disease? How can we match the molecular events in RA pathology with the choice of anti-rheumatic drugs? Great strides have been made toward answering these and other important questions, but clear answers have yet to be found. The answers to these questions will provide some clues for the individualized treatment of RA.
The purpose of this Special Issue is to highlight recent findings regarding the molecular mechanisms of RA. This Special Issue will provide a broad scope of research, including original studies and reviews related to the specific interactions between the immune system and arthritis, genetics, and lifestyle-related risk factors, directly or indirectly affecting the pathogenesis and treatment outcome of the disease.
Prof. Dr. Maria Bokarewa
Dr. Alf Kastbom
Guest Editors
Manuscript Submission Information
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Keywords
- rheumatoid arthritis
- autoimmunity
- metabolism
- risk factors
- treatment
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