DAMPs/Alarmins, Their Distinct Mechanisms of Extracellular Release and Functions
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (1 March 2022) | Viewed by 815
Special Issue Editors
Interests: prothymosin α; stroke; DAMPs/alarmins; chronic pain; fibromyalgia; opioid receptor
Special Issues, Collections and Topics in MDPI journals
Interests: neurological disorders; hypoxia; neurovascular protection; ischemia; DAMPs; angiogenesis
Special Issue Information
Dear Colleagues,
Both pathogen-associated molecular patterns (PAMPs) and damage (danger)-associated molecular patterns (DAMPs/alarmins), are known to produce cytokines and interferons through cell surface and intracellular receptors, and cause inflammatory or cytotoxic events. Unlike PAMPs, DAMPs/alarmins are released from the host cells given stress or damage, such as hypoxia, starvation and heat-shock. The release methods of these molecules are rich in diversity. The whole picture is not clear yet, but recent studies demonstrate a number of mechanisms distinct from the modes of exocytosis. They include the mechanisms through lysosomes (interleukin-1β and high-mobility group box 1), exosomes (galectin-3), exovesicles (galectins and transglutaminase), and transporters (fibroblast growth factor-2). Unique ones are found in the case of stress-induced co-release with S100A13, a cargo protein S100A13 (FGF-1, IL-1α and prothymosin α). Recent study further demonstrates the role of gasdermin D for the release of inflammatory mediators (interleukin-1β). The present Special Issue welcomes the submission of original and review articles related to unique cytotoxic or beneficial actions of DAMPs/alarmins as well as non-classical release mechanisms for DAMPs/alarmins or inflammatory mediators.
Prof. Dr. Hiroshi Ueda
Guest Editor
Dr. Sebok Kumar Halder
Co-Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- exosomes
- exovesicles
- non-classical release
- gasdermin D
- inflammasome
- DAMPs/alarmins
- HMGB1
- S100A13
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
