Immunosuppressive Myeloid Cells in Cancer and Pathophysiological Conditions
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 36981
Special Issue Editors
Interests: glioblastoma; cancer stem cells; myeloid-derived suppressor cells; sex differences; cell communication; immunotherapy
Special Issue Information
Dear Colleagues,
As you are aware, immunosuppressive myeloid cells, including macrophages, myeloid-derived suppressor cells (MDSCs) and neutrophils, are dysregulated in a wide-spectrum of pathophysiological conditions ranging from cancer to autoimmune diseases to infection. In addition to serving as biomarkers, these cells play a central role in the manifestation and progression of disease states by altering immune response and supporting the disease microenvironment. Mechanisms leading to accumulation of immunosuppressive myeloid cells and their downstream impact remain areas of intense research interest and are promising fields for therapeutic development.
This Special Issue seeks original research papers and reviews from a broad range of topics related to the tumor-promoting role of myeloid cells, their function in autoimmune diseases/inflammatory conditions, changes in the myeloid cells in the context of infection/metabolic diseases, their potential as disease biomarkers, heterogeneity in immunosuppressive mechanisms and altered signaling pathways leading to myeloid cell dysfunction.
We look forward to your contribution.
Dr. Justin Lathia
Dr. Defne Bayik
Guest Editors
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Keywords
- myeloid-derived suppressor cells
- macrophages
- granulocytes
- cancer
- malignancy
- inflammation
- autoimmune diseases
- infection
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