Molecular Roadblocks for Cellular Differentiation, Transdifferentiation or Conversion
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (30 September 2020) | Viewed by 213
Special Issue Editors
2. Division of Endocrinology, Diabetes, Nutrition, Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland
Interests: cell fate; cell conversion; regeneration; molecular networks
Special Issues, Collections and Topics in MDPI journals
Interests: hiPSC; differentiation; transgenic models; pancreatic islet biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Homeostasis is a dynamic process. At all stages of life, cell identity is modulated by various factors, usually originating from within the close cellular environment or niche. Cell identity maintenance can therefore be viewed as a dynamic process counteracting the natural trend to change and not a passive/fixed cellular state. The modulation of these cell conversion breaks could prove crucial for treating pathologies characterized by massive cell decay. Moreover, understanding these molecular roadblocks will also improve in vitro differentiation protocols by uncovering molecular inhibitory signals regulating cell fate switches.
This Special Issue in Genes on “Molecular Roadblocks for Cellular Differentiation, Transdifferentiation, or Conversion” will address the responding mechanisms to instructive signals, with a focus on molecular brakes regulating cell identity and thus tissue regeneration or cell differentiation, as described in different experimental models.
Prof. Simona Chera
Dr. Luiza Ghila
Guest Editors
Manuscript Submission Information
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Keywords
- cell differentiation
- transdifferentiation
- cell conversion
- regeneration
- molecular networks
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