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The Role of Stem Cell in Neurodegenerative Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 2596

Special Issue Editor

Special Issue Information

Dear Colleagues,

The lack of curative therapies for neurodegenerative diseases has a high economic impact and places a huge burden on society. The contribution of stem cells to curing neurodegenerative diseases has been unraveled and explored extensively over the past few years. Beyond substitution of the lost neurons, stem cells act as immunomodulators and neuroprotectors. A large number of preclinical and a small number of clinical studies have shown beneficial outcomes in this context. In this Special Issue, we plan to summarize the current concepts of stem cell therapy in neurodegenerative diseases and the recent advances in this field. Further studies should be encouraged to resolve the clinical issues and vague translational findings for maximum optimization of the efficacy of stem cell therapy in neurodegenerative diseases.

Stem cell therapy has revolutionized the field of medicine over the past few decades. Stem cells have been proven to be invaluable in the treatment of numerous diseases affecting various organs in the human body. The list of therapeutic applications of stem cells in clinical practice continues to expand steadily over the years. At a molecular level, there are many parallels among the different forms of neurodegenerative diseases. Unfortunately, among the current available treatment options, neither pharmacological nor neurosurgical ones are efficient in arresting the progression of the neurodegenerative processes. Stem cell therapy, on the other hand, enables regeneration of neural tissue, which ameliorates neurodegeneration occurring at different levels of neuronal circuitry.

We invite you to submit novel research about molecular and cellular mechanisms involving stem cells in neurodegenerative diseases.

Dr. Abdullah Sheikh
Guest Editor

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Keywords

  • stem cells
  • neurodegenerative diseases
  • Parkinson's disease
  • Huntington's disease
  • Alzheimer's disease
  • amyotrophic lateral sclerosis
  • embryonic stem cells
  • induced pluripotent stem cells
  • mesenchymal stem cells
  • neural stem cells

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Published Papers (1 paper)

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Research

15 pages, 2604 KiB  
Article
Alzheimer’s Amyloid β Peptide Induces Angiogenesis in an Alzheimer’s Disease Model Mouse through Placental Growth Factor and Angiopoietin 2 Expressions
by Abdullah Md. Sheikh, Shozo Yano, Shatera Tabassum, Shingo Mitaki, Makoto Michikawa and Atsushi Nagai
Int. J. Mol. Sci. 2023, 24(5), 4510; https://doi.org/10.3390/ijms24054510 - 24 Feb 2023
Cited by 5 | Viewed by 1965
Abstract
Increased angiogenesis, especially the pathological type, has been documented in Alzheimer’s disease (AD) brains, and it is considered to be activated due to a vascular dysfunction-mediated hypoxic condition. To understand the role of the amyloid β (Aβ) peptide in angiogenesis, we analyzed its [...] Read more.
Increased angiogenesis, especially the pathological type, has been documented in Alzheimer’s disease (AD) brains, and it is considered to be activated due to a vascular dysfunction-mediated hypoxic condition. To understand the role of the amyloid β (Aβ) peptide in angiogenesis, we analyzed its effects on the brains of young APP transgenic AD model mice. Immunostaining results revealed that Aβ was mainly localized intracellularly, with very few immunopositive vessels, and there was no extracellular deposition at this age. Solanum tuberosum lectin staining demonstrated that compared to their wild-type littermates, the vessel number was only increased in the cortex of J20 mice. CD105 staining also showed an increased number of new vessels in the cortex, some of which were partially positive for collagen4. Real-time PCR results demonstrated that placental growth factor (PlGF) and angiopoietin 2 (AngII) mRNA were increased in both the cortex and hippocampus of J20 mice compared to their wild-type littermates. However, vascular endothelial growth factor (VEGF) mRNA did not change. Immunofluorescence staining confirmed the increased expression of PlGF and AngII in the cortex of the J20 mice. Neuronal cells were positive for PlGF and AngII. Treatment of a neural stem cell line (NMW7) with synthetic Aβ1–42 directly increased the expression of PlGF and AngII, at mRNA levels, and AngII at protein levels. Thus, these pilot data indicate that pathological angiogenesis exists in AD brains due to the direct effects of early Aβ accumulation, suggesting that the Aβ peptide regulates angiogenesis through PlGF and AngII expression. Full article
(This article belongs to the Special Issue The Role of Stem Cell in Neurodegenerative Diseases)
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