Design, Synthesis and Biological Activity of Heterocyclic Compounds
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 30 March 2025
Special Issue Editor
Interests: organic synthesis; heterocycles; structural analysis; lipophilicity; SAR; molecular docking study
Special Issue Information
Dear Colleagues,
Heterocyclic fragments are present in many natural compounds exhibiting high biological activity. Structure–analysis relationships show that these fragments influence interactions with enzymes’ active sites through the formation of hydrogen bonds and hydrophobic interactions. In medical chemistry, we are observing a trend consisting of the introduction of a moiety with oxygen and nitrogen atoms into non-polar chemical substances. This modification increases the biological activity and bioavailability of new synthetic compounds, especially in terms of water solubility.
This Special Issue on the “Design, Synthesis and Biological Activity of Heterocyclic Compounds” will present the most interesting studies concerning the design of bioactive heterocyclic compounds that could be effective drugs. Additionally, it will also focus on studies dealing with compound bioavailability and interactions with different biological targets.
Dr. Monika Kadela-Tomanek
Guest Editor
Manuscript Submission Information
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Keywords
- synthesis of new bioactive compounds
- biological activity of heterocyclic compounds
- structural analysis
- pharmacokinetic analysis of potential drugs
- molecular docking study of new heterocyclic compounds
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