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Eosinophils: Current Status and Future Perspective in Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (30 July 2024) | Viewed by 2999

Special Issue Editor


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Guest Editor
Department of Translational Medical Sciences, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy
Interests: allergy; asthma; Immune; lipopolysaccharide; lung; monocytes; macrophages

Special Issue Information

Dear Colleagues,

Eosinophils play a key role in physiological processes, such as metabolism, tissue remodelling, microbiome regulation, and combating infections. Eosinophils-mediated inflammation is also involved in many pathological conditions, including asthma, chronic rhinosinusitis with nasal polyps, gastrointestinal disorders, vasculitis, hypereosinophilic syndromes, and certain cancers. In recent years, the introduction of biological drugs targeting eosinophils has greatly increased the interest in these cells, which is now a field of changing perspectives and new emerging directions.

This broad research theme welcomes original research, meta-analyses, and review articles from several perspectives, including basic, clinical, and translational research. This collection aims to provide important insight into the role of eosinophils in tissue homeostasis, host defence, and pathological conditions. We also encourage the submission of manuscripts focusing on eosinophil biology, the characterization of their subtypes, the novel biomarkers of eosinophilic activation, and eosinophil-targeted biologics.

This Special Issue is supervised by Dr. Francescopaolo Granata and assisted by our Topical Advisory Panel Member Dr. Ilaria Mormile (University of Naples Federico II). We look forward to receiving your contributions to this Special Issue.

Dr. Francescopaolo Granata
Guest Editor

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Keywords

  • eosinophils
  • inflammation
  • hypereosinophilic syndrome
  • asthma
  • allergic disease
  • biomarkers
  • cytokines
  • IL-5
  • biologic drugs

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Published Papers (1 paper)

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Review

18 pages, 2585 KiB  
Review
Eosinophils in Oral Disease: A Narrative Review
by Huda Moutaz Asmael Al-Azzawi, Rita Paolini, Nicola Cirillo, Lorraine Ann O’Reilly, Ilaria Mormile, Caroline Moore, Tami Yap and Antonio Celentano
Int. J. Mol. Sci. 2024, 25(8), 4373; https://doi.org/10.3390/ijms25084373 - 16 Apr 2024
Cited by 2 | Viewed by 2397
Abstract
The prevalence of diseases characterised by eosinophilia is on the rise, emphasising the importance of understanding the role of eosinophils in these conditions. Eosinophils are a subset of granulocytes that contribute to the body’s defence against bacterial, viral, and parasitic infections, but they [...] Read more.
The prevalence of diseases characterised by eosinophilia is on the rise, emphasising the importance of understanding the role of eosinophils in these conditions. Eosinophils are a subset of granulocytes that contribute to the body’s defence against bacterial, viral, and parasitic infections, but they are also implicated in haemostatic processes, including immunoregulation and allergic reactions. They contain cytoplasmic granules which can be selectively mobilised and secrete specific proteins, including chemokines, cytokines, enzymes, extracellular matrix, and growth factors. There are multiple biological and emerging functions of these specialised immune cells, including cancer surveillance, tissue remodelling and development. Several oral diseases, including oral cancer, are associated with either tissue or blood eosinophilia; however, their exact mechanism of action in the pathogenesis of these diseases remains unclear. This review presents a comprehensive synopsis of the most recent literature for both clinicians and scientists in relation to eosinophils and oral diseases and reveals a significant knowledge gap in this area of research. Full article
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