Adipose Tissue and Its Role in Metainflammatory Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 20 February 2025 | Viewed by 78
Special Issue Editor
Special Issue Information
Dear Colleagues,
Adipose tissue, namely the abdominal white pad, plays a relevant role in metainflammation after injury. This is a consequence arising from white adipocyte hypertrophy, cells that enhance proinflammatory adipokine production (synthesis and secretion) in addition to infiltrating, and resident adipose tissue macrophages will cooperate to further increase proinflammatory cytokine production, thus aggravating the inflammation in combination with both local tissue cells and distanced tissues’ insulin resistance. Serious consequences are then triggered, inducing many organs’ dysfunctions, such as dyslipidemia, augmented liver glucose production, decreased muscle glucose utilization, pancreatic beta cell apoptosis, vascular endotheliatis, arterial hypertension, atherosclerosis, enhanced heart contractility, impaired renal glucose clearance and neuroinflammation. As a result, there is an increased risk for the development of metabolic syndrome, cardiovascular disease, obesity, type 2 diabetes mellitus, stroke and neurodegenerative diseases. However, due to adaptive organisms’ defense mechanisms, the brown adiposity and white adiposity browning functions, as well as those of the immune and autonomous nervous systems play crucial counteracting roles to cope undesirable events from installed insulin resistance-induced metainflammation.
Dr. Eduardo J. Spinedi
Guest Editor
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Keywords
- adipogenesis
- adipokines
- browning
- insulin resistance
- DMT2
- metainflammation
- WAT–brain axis
- atherosclerosis
- metabolic syndrome
- obesity
- neuroinflammation
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