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Physiology and Pathophysiology of Placenta: 3rd Edition

Special Issue Editor


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Guest Editor
Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Via Tronto, 10/a, 60126 Ancona, Italy
Interests: pregnancy complications; preeclampsia; preterm birth; ovarian cancer; early marker of pregnancy complications; oxidative stress; chemoresistance
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Special Issue Information

Dear Colleagues,

This is a continued series of the hot topic of "Physiology and Pathophysiology of Placenta". We already have done successful special issues that received interesting contributions and discussions.

The development and differentiation of placental villous tree are two key process tightly regulated during pregnancy. In fact, several growth factors, their receptors and other types of molecules can regulate placental cell proliferation, differentiation, migration and invasion. Thus, an impairment of normal placental development can lead to a series of pregnancy pathologies, i.e., preeclampsia (PE), fetal growth restriction (FGR), gestational trophoblastic diseases (GTD) and gestational diabetes mellitus (GDM). Furthermore, external factors, such as microbial agents, chemicals and natural compounds can affect placental development and function impairing pregnancy outcome.

These pregnancy complications result in increased maternal and fetal mortality and morbidity leading to life-long health implications in both mother and child.

The aim of this Special Issue is to provide an overview of the placental development and pathophysiology in order to better understand the molecular mechanisms involved in pregnancy. We are inviting submissions of original research articles, reviews and mini-reviews on topics relevant to any aspect of placental physiology, pathophysiology, biochemistry and molecular biology.

Dr. Giovanni Tossetta
Guest Editor

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Keywords

  • trophoblast
  • proliferation
  • differentiation
  • invasion
  • placenta
  • preeclampsia
  • fetal growth restriction
  • gestational diabetes mellitus
  • infection
  • pregnancy complications

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