Development and Application of Antifungal Materials
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 107
Special Issue Editor
Special Issue Information
Dear Colleagues,
The rapidly increasing incidence of fungal infections, particularly among high-risk populations such as cancer patients, individuals with HIV, organ transplant recipients, and those undergoing immunosuppressive therapy, is exacerbated by the rise in drug-resistant and multidrug-resistant strains, leading to invasive fungal infections.
The limited number of available antifungals, high rate of resistance, drug-induced toxicity, and drug–drug interactions pose an urgent need to develop new antifungal agents with efficient activity, no cross resistance to existing antifungal classes, and new modes of action.
In recent decades, researchers have focused on developing antifungal agents with several ideal properties: (a) high selectivity for fungal targets and novel modes of action, (b) favorable pharmacokinetics, (c) appropriateness for oral, intravenous, and/or inhaled administration, (d) low toxicity to hosts, and (e) fungicidal rather than fungistatic activity. In response to global need, the aim of this Special Issue (SI) is to provide a comprehensive overview of the current advancements in the development of novel antifungal agents. It addresses One Health concerns related to combating resistant fungal infections, proposes innovative therapeutic strategies to overcome resistance mechanisms, and seeks to enhance patient outcomes. Original research articles, review articles, perspectives, and short communications are welcome.
Dr. Maryam Roudbary
Guest Editor
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Keywords
- fungal infection
- drug resistance
- novel agents
- mode of action
- therapeutic strategies
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