Tumor Microenvironment and Its Actors: Are Ion Channels Relevant?
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 11451
Special Issue Editors
Interests: glioblastoma; TRP channel; mucolipins; autophagy; overall survival; transient receptor potential channels; tumor progression; chemotherapy resistance;cancer biology; cancer stem cell; circulating tumor cell; liquid biopsy; biomarkers; ion channel; natural compound; cannabinoids
Special Issues, Collections and Topics in MDPI journals
Interests: TRP; cancer biology; apoptosis; autophagy; senescence; circulating stem cell; chemoresistance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer research is opening new perspectives in the field of patient management, focusing mainly on factors that promote tumor progression. The environment surrounding the tumor mass, consisting of resident cells and extracellular matrix, plays an important role in maintaining a condition conducive to the growth and progression of the disease. This also results in the establishment of resistance to the main therapeutic standards, such as chemotherapy and radiotherapy. Oncology research is making great strides, bringing to light new prognostic and therapeutic biomarkers. Among all, it has been demonstrated that the ion channel family is involved in several type of cancers. For this reason, the goal of this Special Issue is to bring together experts and scientists who work on ion channels to collect information and data regarding their involvement not only in tumor but also in its microenvironment.
The ultimate purpose is to identify, at the molecular level, the contribution of ion channels to the various cancerous processes, ranging from signaling pathways involved in tumor growth, invasion, angiogenesis, drug resistance, metastasis formation, up to immune escape.
Dr. Maria Beatrice Morelli
Dr. Amantini Consuelo
Guest Editors
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Keywords
- ion channels
- tumor microenvironment
- niche
- calcium signaling
- mechanism
- leukocyte
- fibroblast
- endothelial cell
- metastasis
- angiogenesis
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