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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Hyperelastic Structures submission deadline 20 Mar 2025 | Viewed by 308 | Submission Open
Keywords: hyperelastic structures; biological properties; molecular properties; nonlinear elasticity; soft structures; material modeling
(This special issue belongs to the Section Materials Science)
Advances in Telomeres and Interstitial Telomeric Sequences
edited by Anna Y Aksenova
submission deadline 20 Mar 2025 | Viewed by 298 | Submission Open
Keywords: telomeres; telomerase; interstitial telomeric sequences; alternative lengthening of telomeres; genome instability; aging; cancer
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Advances in Mental Health and Disorders
edited by Eva Christina Schulte
submission deadline 20 Mar 2025 | Viewed by 247 | Submission Open
Keywords: molecular studies; mental health disorders; model systems; molecular epidemiology; omics   TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified ChinesePRO Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetic, Epigenetic and Microbiota Molecular Insights for Crop Resilience to Abiotic Stress in Times of Climate Change
edited by
submission deadline 20 Mar 2025 | Viewed by 230 | Submission Open
Keywords: abiotic stress; tolerance; crop resilience; crop sustainability; environmental conditions; climate change; gene regulation; epigenetic mechanisms; microbiota communities; microbiome
(This special issue belongs to the Section Molecular Plant Sciences)
Biomaterials and Tissue Regeneration in Craniofacial Defect Reconstruction
edited by and Horia Barbu
submission deadline 20 Mar 2025 | Viewed by 226 | Submission Open
Keywords: biomaterials; biocompatibility; tissue engineering; craniofacial defect; oral rehabilitation; scaffolds; regenerative medicine; angiogenesis; stem cells
(This special issue belongs to the Section Materials Science)
Immune Responses to Viruses
edited by , Tarik Gheit and
submission deadline 20 Mar 2025 | Viewed by 222 | Submission Open
Keywords: viruses; innate immunity; cellular signaling; viral infections; cell– host interactions; virus-mediated cellular transformation; immune response; viral escape
(This special issue belongs to the Section Molecular Immunology)
Radiation Resistance in Extremophile Bacteria: Unraveling the Molecular Mysteries submission deadline 20 Mar 2025 | Viewed by 216 | Submission Open
Keywords: extremophiles; radiation resistance; genome analysis; RNAseq; proteome studies; comparative analysis; molecular mechanisms; genetic adaptation; metabolic shifts; evolutionary insights; eukaryotic resistance
(This special issue belongs to the Section Molecular Microbiology)
Molecular Insights into Streptococcus pneumoniae
edited by Lok-To Sham
submission deadline 20 Mar 2025 | Viewed by 212 | Submission Open
Keywords: respiratory pathogen; Streptococcus pneumoniae; host– pathogen interactions; gene function
(This special issue belongs to the Section Molecular Microbiology)
Molecular and Cellular Research in Pregnancy-Related Complications, 2nd Edition submission deadline 20 Mar 2025 | Viewed by 206 | Submission Open
Keywords: pregnancy loss/miscarriage; pregnancy complications; pre-eclampsia; maternal– placental– fetal interactions; trophoblast; immune cells; immune tolerance; red blood cells; oxidative stress; blood and fetal proteins; DNA; RNA; stem cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Roles of Mast Cells in Immune-Induced Diseases
edited by Paul L.A. Van Daele and Willem A. Dik
submission deadline 20 Mar 2025 | Viewed by 170 | Submission Open
Keywords: mast cell; fibrosis; inflammation; autoinflammation; autoimmunity; transplantation; gastrointestinal; pulmonary; cytokines; MRGPRX2; rejection
(This special issue belongs to the Section Molecular Immunology)
The Role of Hypoxia, Normoxia and Hyperoxia in Cancer Initiation and Propagation
edited by Mary M. Salvatore
submission deadline 20 Mar 2025 | Viewed by 163 | Submission Open
Keywords: hypoxia; normoxia; hyperoxia; cancer initiation; cancer propagation
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Transplantation and Machine Perfusion submission deadline 20 Mar 2025 | Viewed by 74 | Submission Open
Keywords: transplantation (liver; kidney; and other organs); primary failure; ischemia-reperfusion injury; static graft preservation; HOPE; NMP; cell signaling; glycocalyx; metabolomics; mitochondria; sterile inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Extracellular Vesicles: From Molecular Mechanisms to Therapeutic Applications
edited by Jung-Hyun Lee
submission deadline 20 Mar 2025 | Viewed by 60 | Submission Open
Keywords: extracellular vesicles; intercellular communications; biomarkers; drug delivery systems
(This special issue belongs to the Section Biochemistry)
Neuronal Differentiation: From Pathology to Therapeutic Strategies
edited by
submission deadline 20 Mar 2025 | Viewed by 46 | Submission Open
Keywords: neuronal differentiation; molecular mechanisms of neurodifferentiation; neurodegenerative diseases; ischemic stroke; spinal cord and brain injury; neural tissue recovery; regeneration therapy; stem cells
(This special issue belongs to the Section Molecular Neurobiology)
Antimicrobial Agents: Synthesis and Design
edited by
submission deadline 20 Mar 2025 | Viewed by 34 | Submission Open
Keywords: multi-drug resistant Gram-negative and Gram-positive pathogens; clinically relevant superbugs; severe and almost untreatable infections; immunocompromised individuals; synthetic antimicrobial cationic macromolecules; synthetic cationic dendrimers; polymers; and copolymers; polymerizing strategies; quaternary ammonium and phosphonium salts; amino-acid modified macromolecules; electrostatic interactions and membrane permeabilization; membrane disruptors; drug delivery systems; cationic bola-amphiphiles
(This special issue belongs to the Section Materials Science)
Plant Resistance to Biotic and Abiotic Stresses
edited by and
submission deadline 20 Mar 2025 | Viewed by 31 | Submission Open
Keywords: biotic stress; abiotic stress; resistance; molecular mechanisms; molecular biology; plant disease; plant pathogens; drought; salinity; extreme temperatures
(This special issue belongs to the Section Molecular Plant Sciences)
The Molecular Role of Platelets in Human Diseases submission deadline 20 Mar 2025 | Viewed by 23 | Submission Open
Keywords: platelet; biomarkers; platelet membrane proteins; platelet-derived microparticles; platelet-related diseases; thrombosis; inflammatory diseases; cardiovascular disease; cancer; tumor growth and metastasis
(This special issue belongs to the Section Molecular Biology)
Design of Bioactive Agents and Interaction with Biological Systems
edited by
submission deadline 20 Mar 2025 | Viewed by 12 | Submission Open
Keywords: natural and synthetic compounds; bioactive agents and materials; design and discovery; targeting; intermolecular interactions; omics; structure and dynamics of biomolecules; theoretical analysis of biomolecular structures; analytical and biophysical methods; molecular biology/biochemistry; chemical biology/biological chemistry
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Endometrial Cancer
edited by Ursula Catena
submission deadline 20 Mar 2025 | Viewed by 11 | Submission Open
Keywords: endometrial cancer; risk factors; early detection; molecular profiling; targeted therapy; immunotherapy; surgical management; fertility-sparing treatment; quality of life
(This special issue belongs to the Section Molecular Oncology)
Potential Health Benefits of Resveratrol: Laboratory-Confirmed Mechanisms of Action
edited by
submission deadline 20 Mar 2025 | Viewed by 8 | Submission Open
Keywords: resveratrol; polyphenol; phytoalexin; phytoestrogen; natural compound; reactive oxygen species; antioxidant effects; anti-inflammatory effects; antiaging properties; antidiabetic properties; cardioprotective effects; neuroprotective effects; anticancer properties
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Blood Cells in Human Health and Disease
edited by Leonid Livshits
submission deadline 25 Mar 2025 | Viewed by 93 | Submission Open
Keywords: red blood cell; RBC membrane; RBC biophysical properties; RBC rheology; RBC mechanical properties; RBC membrane vesiculation; RBC clearance; RBC in diabetes; hemoglobinopathies; RBC storage TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Biochemistry)
Navigating Lung Cancer in the Era of Cancer Pharmacology and Precision Therapy
edited by
submission deadline 25 Mar 2025 | Viewed by 92 | Submission Open
Keywords: lung cancer; pharmacology; precision therapy; targeted therapy; immunotherapy; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Big Data in Multi-Omics submission deadline 25 Mar 2025 | Viewed by 82 | Submission Open
Keywords: data science; big data; omics; data management; data analytics TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in Shona   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate Shona to Simplified Chinese Never translate Shona Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Informatics)
Biological Pathways and Nutraceutical Compounds in Genetic Disease Treatment
edited by
submission deadline 25 Mar 2025 | Viewed by 63 | Submission Open
Keywords: micronutrients; supplements; functional foods; inherited disease; microbiome; RNA expression; protein expression; signaling pathways; DNA methylation; animal models; cell lines; clinical trials
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular and Physiological Mechanisms of Exercise
edited by Zoran Nikolovski
submission deadline 25 Mar 2025 | Viewed by 61 | Submission Open
Keywords: molecular biology; biochemistry and exercise; athletic performance; multi-omic
(This special issue belongs to the Section Molecular Biology)
Integrated Approaches, Molecular Mechanism and Therapies in Ocular Surface Diseases
edited by , and
submission deadline 25 Mar 2025 | Viewed by 51 | Submission Open
Keywords: ocular surface diseases; dry eye; corneal ulcers; persistent epithelial defects; blood-derived products; blood-based therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Innovative Biological Molecules for Cancer Therapy
edited by
submission deadline 25 Mar 2025 | Viewed by 31 | Submission Open
Keywords: cancer treatment; immunotherapy; biological therapy; natural products; active molecule; biological peptide; antibody; nucleic acid; pharmacology
(This special issue belongs to the Section Molecular Biology)
Roles and Mechanisms of Non-Coding RNAs in Breast Cancer
edited by
submission deadline 25 Mar 2025 | Viewed by 14 | Submission Open
Keywords: breast cancer; NcRNA; MmiRNA; LncRNA; CircRNA; PiRNA; exosome-packed ncRNA; role and mechanisms of ncRNA in breast cancer tissue or cell lines; modulation of ncRNA levels by knock-out or knock-down approaches; effects on breast cancer cell proliferation; invasion; or apoptosis; identification of BC-relevant ncRNA– mRNA networks; targeting ncRNAs with potential clinical implications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Anti-Inflammatory and Metabolic Effects of G Protein-Coupled Receptor Signaling
edited by
submission deadline 28 Mar 2025 | Viewed by 34 | Submission Open
Keywords: G protein-coupled receptors (GPCRs); seven transmembrane domain (7TM) receptors; metabotropic receptors; membrane receptors; GPCRs signaling; GPCRs signaling pathways; anti-inflammatory effects; inflammatory diseases; metabolic diseases; metabolic effects; anti-inflammatory treatment
(This special issue belongs to the Section Molecular Immunology)
Application of Genetic Engineering in Treatments for Human Diseases
edited by Claudio Mussolino
submission deadline 28 Mar 2025 | Viewed by 17 | Submission Open
Keywords: genome editing; epigenome editing; CRISPR-Cas systems; gene therapy; precision medicine; molecular mechanisms; innovative therapies; gene expression regulation
(This special issue belongs to the Section Molecular Genetics and Genomics)
Cytochrome P450: Metabolism, Structure-Function, Evolution and Applications submission deadline 30 Mar 2025 | 1 articles | Viewed by 1580 | Submission Open
Keywords: cytochrome P450 monooxygenase; metabolism; structure-function; evolution; applications
(This special issue belongs to the Section Biochemistry)
Clinical and Biological Perspectives on Apoptosis
edited by Syed Qadri, Rosi Bissinger and
submission deadline 30 Mar 2025 | 1 articles | Viewed by 1051 | Submission Open
Keywords: erythrocytes; apoptosis; eryptosis; anemia; systemic diseases
(This special issue belongs to the Section Molecular Biology)
Survival of the Fittest: Physiological Adaptations of Insects in Hostile Environments submission deadline 30 Mar 2025 | Viewed by 64 | Submission Open
Keywords: insect adaptation; temperature tolerance; insect physiology; detoxification; symbiosis and stress tolerance mechanisms
(This special issue belongs to the Section Molecular Biology)
T Cells in Immune Diseases: Regulation and Function
edited by Chia-Rui Shen
submission deadline 30 Mar 2025 | Viewed by 29 | Submission Open
Keywords: T cell function; T cells in immune diseases; regulation and function
(This special issue belongs to the Section Molecular Immunology)
Interactions of Plants with Bacteria and Fungi
edited by
submission deadline 30 Mar 2025 | Viewed by 25 | Submission Open
Keywords: plant– pathogen interaction; plant protection; multidisciplinary approaches; environmental sustainability; pathogen evolution; food security; plant health
(This special issue belongs to the Section Molecular Plant Sciences)
Research in Novel Immune Adjuvants
edited by Bei Li
submission deadline 30 Mar 2025 | Viewed by 22 | Submission Open
Keywords: adjuvants; vaccine; immunology; toxicology; biology
(This special issue belongs to the Section Molecular Immunology)
Pathogenesis and Treatment of Prostate Cancer submission deadline 30 Mar 2025 | Viewed by 19 | Submission Open
Keywords: prostate cancer; pathogenesis; genetic mutations; target therapy; surgery; radiation therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Molecular Breeding and Resistance: Phenomics, Genomics and Gene Editing—Second Edition
edited by
submission deadline 30 Mar 2025 | Viewed by 1 | Submission Open
Keywords: plant; molecular breeding; plant resistance; plant abiotic stress; plant biotic stress; throughput phenotyping; plant phenomics; plant phenomics; plant genetics; genetic variation; gene editing; CRISPR/Cas9; plant computational modeling
(This special issue belongs to the Section Molecular Plant Sciences)
Respiration and Photosynthetic Function in Plants
edited by
submission deadline 30 Mar 2025 | Viewed by 1 | Submission Open
Keywords: photosynthesis; day and dark respiration; photorespiration; water relations; metabolism; partitioning; carbon budget; nutrients; isotopes; allocation; phloem; gas exchange
(This special issue belongs to the Section Molecular Plant Sciences)
Design, Synthesis and Biological Activity of Heterocyclic Compounds submission deadline 30 Mar 2025 | Submission Open
Keywords: synthesis of new bioactive compounds; biological activity of heterocyclic compounds; structural analysis; pharmacokinetic analysis of potential drugs; molecular docking study of new heterocyclic compounds
(This special issue belongs to the Section Biochemistry)
Advances in Plant Genomics and Genetics: 2nd Edition
edited by
submission deadline 30 Mar 2025 | Submission Open
Keywords: plant genomics; plant genetics; abiotic stresses; salt resistance; genome; next-generation sequencing
(This special issue belongs to the Section Molecular Genetics and Genomics)
Tryptophan in Nutrition and Health 3.0
edited by
submission deadline 31 Mar 2025 | 7 articles | Viewed by 12120 | Submission Open
Keywords: antioxidants; kynurenine; melatonin; serotonin; tryptophan
(This special issue belongs to the Section Molecular Pharmacology)
Mechanisms Underlying Cancer Chemoresistance: A Starting Point to Identify New Anticancer Strategies submission deadline 31 Mar 2025 | 5 articles | Viewed by 9563 | Submission Open
Keywords: chemoresistance; drug uptake; cancer stemness; redox metabolism; antioxidants; apoptosis; senescence; autophagy; miRNAs; target therapy
(This special issue belongs to the Section Molecular Oncology)
State-of-the-Art Molecular Biology in Chile, 2nd Edition submission deadline 31 Mar 2025 | 2 articles | Viewed by 5470 | Submission Open
Keywords: molecular biology; Chilean scientists; neurophysiology; physiology and cellular physiology; genetics; ecology; immunology; pharmacology
(This special issue belongs to the Section Molecular Biology)
Advances in Spermatogenesis and Male Infertility
edited by Wanxi Yang
submission deadline 31 Mar 2025 | 2 articles | Viewed by 2101 | Submission Open
Keywords: male reproduction; hormone regulation; blood– testis barrier; male reproductive diseases; male infertility
(This special issue belongs to the Section Molecular Biology)
Signal Transduction Mechanism in Plant Disease and Immunity 2nd Edition submission deadline 31 Mar 2025 | 2 articles | Viewed by 1797 | Submission Open
Keywords: plant disease resistance; biotic stress; pathogen; plant-microbe interaction; priming; signal transduction; phytohormone; proteomics
(This special issue belongs to the Section Molecular Plant Sciences)
Musculoskeletal Disorders: From Molecular Pathology to Novel Therapeutic Approach submission deadline 31 Mar 2025 | 1 articles | Viewed by 521 | Submission Open
Keywords: joints; skeletal muscles; tendons; ligaments; fascia; articular cartilage; intervertebral discs; physiotherapy; novel therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Aspects of Bacterial Infection submission deadline 31 Mar 2025 | Viewed by 114 | Submission Open
Keywords: bacterial pathogenesis; antimicrobial resistance; molecular mechanism of host-pathogen interaction; biofilm; infectious diseases
(This special issue belongs to the Section Molecular Microbiology)
Liposomes: Molecular Marvels in Drug Delivery submission deadline 31 Mar 2025 | Viewed by 56 | Submission Open
Keywords: liposomal drug; targeted delivery; controlled release; hydrogen bonding; long-term stability; archaeosomes; cytotoxicity; lyophilized liposomal drugs
(This special issue belongs to the Section Molecular Biophysics)
Adaptations of Plant Metabolism and Their Consequences on Nutritive Potential and Bioactivity, 2nd Edition
edited by
submission deadline 31 Mar 2025 | Viewed by 53 | Submission Open
Keywords: plant primary metabolism; plant specialized metabolism; phytochemistry; plant bioactive components; plant metabolic plasticity; plant nutritional value; bioactivity of plant extracts; plant– stress response; abiotic stress; climate change; global warming; environmental pressure; biotic stress; anthropogenic influence on plant metabolites; predictive models
(This special issue belongs to the Section Molecular Plant Sciences)
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