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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Liver Fibrosis: Molecular Pathogenesis, Diagnosis and Treatment

edited by Manuel Morales-Ruiz

submission deadline 31 Mar 2025 | Viewed by 30 | Submission Open

Keywords: liver fibrosis; cirrhosis; hepatic stellate cells; collagen; fibrogenic pathways; diagnosis of fibrosis; therapeutic strategies for liver disease; extracellular matrix remodeling; cell-to-cell interactions; fibrosis complications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Drug Treatment in Alzheimer’s Disease

edited by

Roberto Dominici

and Diego Dolcetta

submission deadline 31 Mar 2025 | Viewed by 29 | Submission Open

Keywords: Alzheimer’ s disease (AD); glia; immune system; neurotoxicity; inflammation; beta-Amyloid (bA); neurofibrillary tangles (NFTs)

(This special issue belongs to the Section Molecular Neurobiology)

Composites of Carbon Nanomaterials and Transition Metals: Preparation, Properties, Bioapplications

edited by

Robert Piech

submission deadline 31 Mar 2025 | Viewed by 29 | Submission Open

Keywords: composite materials; carbon nanomaterials; nanoparticles of transition metals and their compounds; preparation and functionalization of composite materials; biosensors; bioapplications

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Novel Therapeutic Strategies in Diabetes

edited by

Aikaterini Andreadi

submission deadline 31 Mar 2025 | Viewed by 29 | Submission Open

Keywords: diabetes mellitus; type 1 and type 2 diabetes; GLP1-RA; SGLT2i; smart pen and CSII; micro and macrovascular complications; cardiovascular risk; diabetic foot

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

ROS Signalling and Cell Turnover

edited by

Micol Silic-Benussi

submission deadline 31 Mar 2025 | Viewed by 28 | Submission Open

Keywords: metabolism; lipid droplets; nanoparticles; ROS; cancer therapy; redox homeostasis; mitochondria; cell death

(This special issue belongs to the Section Biochemistry)

Chemistry Triggered by Low-Energy Particles

edited by Hassan Abdoul-Carime

submission deadline 31 Mar 2025 | Viewed by 27 | Submission Open

Keywords: low energy (< 50 eV); photons; electrons; ions; gas phase; single molecules; clusters; condensed phase liquids and films; experimental techniques; density functional theory; IA-based prediction models

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Advances in Analytical Techniques for Biological and Medical Research: 2nd Edition

edited by

Angela Di Capua

and

Maria Assunta Acquavia

submission deadline 31 Mar 2025 | Viewed by 27 | Submission Open

Keywords: HPLC; GC; electrophoresis; mass spectrometry; plant materials; validation; metabolomics; proteomics; protein– ligand interaction.

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Diabetes—2nd Edition

edited by

Alessandra Puddu

and

Davide Maggi

submission deadline 31 Mar 2025 | Viewed by 26 | Submission Open

Keywords: diabetes; insulin; glucose metabolism; oxidative stress

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Therapies and Strategies in the Treatment of Neurodegenerative Diseases

edited by

Polina Petkova-Kirova

submission deadline 31 Mar 2025 | Viewed by 25 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; aging; memory; dementia; motor dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Molecular Mechanisms of Genotoxicity

edited by Francesca Marcon

submission deadline 31 Mar 2025 | Viewed by 22 | Submission Open

Keywords: DNA damage; DNA repair; genotoxicity; carcinogenesis; chronic degenerative diseases; human health; molecular mechanisms

(This special issue belongs to the Section Molecular Toxicology)

Microbiome Connections in Age-Related Diseases

edited by Shalini Jain

submission deadline 31 Mar 2025 | Viewed by 21 | Submission Open

Keywords: microbiome; aging; age-related diseases; Alzheimer’ s; dementia

(This special issue belongs to the Section Molecular Microbiology)

Neuroinflammation: From Molecular Mechanisms to Therapy

edited by

Silvia Alboni

and Miriam Ciani

submission deadline 31 Mar 2025 | Viewed by 19 | Submission Open

Keywords: neuroinflammation; neurodegenerative diseases; psychiatric disorders; molecular and cellular targets

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Perspective in Autoimmune Diseases

edited by Andrés González-García

submission deadline 31 Mar 2025 | Viewed by 17 | Submission Open

Keywords: interferon; cytokines; lupus nephritis; lupus; type I interferon; vasculitis; IgG4-related disease; B cell; NETs; IL-6; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Circumventing Resistance to Channel-Targeting Insecticides: A Challenge for Global Health and Food Security

edited by

Bruno Lapied

and David Barry Sattelle

submission deadline 31 Mar 2025 | Viewed by 16 | Submission Open

Keywords: pest insects and resistance; resistance in insect vectors of human and livestock diseases; mechanisms of resistance; circumventing resistance; ion channels and resistance; integrated approaches to resistance management; alternating insecticide classes; minimizing risk to beneficial insects; novel control strategies

(This special issue belongs to the Section Molecular Biology)

Molecular Genetics and Breeding Mechanisms in Domestic Animals: 3rd Edition

edited by

Guiping Zhao

submission deadline 31 Mar 2025 | Viewed by 16 | Submission Open

Keywords: animal genetics; animal breeding; functional genomics; multiomics analysis; molecular immunity; interactions between microbe and host

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Role of Extracellular Matrix Proteins in Pathogenesis: 2nd Edition

edited by

Davide Raineri

submission deadline 31 Mar 2025 | Viewed by 16 | Submission Open

Keywords: extracellular matrix proteins; autoimmune disease; cancer; cardiovascular diseases; inflammation; chronic diseases; human diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Food Processing Industry’s 200th Anniversary: Bioactive Compounds, Antioxidants, and Potential Health Benefits (2nd Edition)

edited by

Vassilis Athanasiadis

submission deadline 31 Mar 2025 | Viewed by 11 | Submission Open

Keywords: antioxidants; bioactive compounds; food processing; functional foods; green processes; health potentials; molecular mechanisms; polyphenols; shelf life; vitamins

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Biomolecular Basis of Life Processes

edited by

Janusz Błaszczyk

submission deadline 31 Mar 2025 | Viewed by 11 | Submission Open

Keywords: energy metabolism; bone-muscle interaction; ATP signalling; calcium– phosphate signalling; metabolic syndrome; aging; cellular turnover; cancers

(This special issue belongs to the Section Molecular Biology)

Cancer Biomarkers and Metabolic Vulnerabilities

edited by Francesca Bersani

submission deadline 31 Mar 2025 | Viewed by 10 | Submission Open

Keywords: cancer metabolism; cancer biomarkers; liquid biopsy; therapeutic targets; metabolic rewiring

(This special issue belongs to the Section Biochemistry)

RNA Modifications in Response to Physical Activity: Implications for Rehabilitation and Disease Management

edited by Roberto Tedeschi and Francesca Gorini

submission deadline 31 Mar 2025 | Viewed by 9 | Submission Open

Keywords: RNA modifications; non-coding RNAs (ncRNAs); physical activity; gene expression; rehabilitation and disease management; epigenetic regulation; exercise-induced RNA expression; miRNA in inflammation control

(This special issue belongs to the Section Molecular Biology)

The Zebrafish Model in Animal and Human Health Research, 2nd Edition

edited by

Antonella Marino Gammazza

and

Marta Anna Szychlinska

submission deadline 31 Mar 2025 | Viewed by 9 | Submission Open

Keywords: zebrafish; environmental toxicology; predictive toxicology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Pathogen Dynamics: Enhancing One Health Surveillance

edited by

Franklin W.N. Chow

and

Chi-Ching Tsang

submission deadline 31 Mar 2025 | Viewed by 6 | Submission Open

Keywords: pathogens; pathogen dynamics; infectious diseases; molecular omics; wet lab experiments; phenotypic analyses; bacterial; viral; fungal; parasitic pathogens; zoonotic diseases; vector-borne Diseases; antimicrobial resistance; interplay between pathogens and hosts/environment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Screening and Identification of Crop Abiotic Stress Tolerance Functional Genes

edited by

Liezhao Liu

submission deadline 31 Mar 2025 | Viewed by 2 | Submission Open

Keywords: plant; abiotic stress; gene; identification; function

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Biology of Cucurbitaceae Family Plants

edited by

Magdalena Pawełkowicz

submission deadline 31 Mar 2025 | Viewed by 1 | Submission Open

Keywords: vascular biology; floral development; sex expression; fruit development; grafting; source– sink interactions; genetic resources; stress tolerance; molecular breeding; gene regulation; resistance to biotic and abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Pathology, Diagnostics, and Therapeutics in Optic Neuropathies

edited by Tsz Kin Ng

submission deadline 31 Mar 2025 | Submission Open

Keywords: optic neuropathies; glaucoma; optic nerve; retinal ganglion cells; neuroprotection; biomarkers; pathophysiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Exercise-Induced Metabolic Physiology

edited by

Kijin Kim

and Jinho Koh

submission deadline 31 Mar 2025 | Submission Open

Keywords: exercise; physiology; metabolism; molecular biology; biochemistry; aging; metabolic syndrome

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Blueprints of Enzymatic Function and Structure in Biocatalysis

edited by

Francesco Malatesta

submission deadline 31 Mar 2025 | Submission Open

Keywords: enzyme; biocatalysis; enzyme structure; enzyme kinetics and thermodynamics; enzyme engineering; synthetic biology applications; sustainable biocatalyst design

(This special issue belongs to the Section Biochemistry)

Molecular Genetics, Breeding, and Multi-Omics Approaches in Rice Research

edited by

Zakaria Prodhan

submission deadline 31 Mar 2025 | Submission Open

Keywords: rice genetics and breeding; molecular breeding of rice; rice genomics and proteomics; genes related to abiotic stress tolerance in rice; molecular biology and multi-omics in rice research

(This special issue belongs to the Section Molecular Plant Sciences)

Investigation of Natural Products as Sources of Bioactive Molecules, 2nd Edition

edited by

Stefania Garzoli

submission deadline 31 Mar 2025 | Submission Open

Keywords: metabolomic; secondary metabolites; phytochemical analysis; bioactivity; chemical investigation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Protein Phosphorylation in Genetic Diseases

edited by

Christian Borgo

and

Mauro Salvi

submission deadline 15 Apr 2025 | 2 articles | Viewed by 4984 | Submission Open

(This special issue belongs to the Section Biochemistry)

New Challenges and Opportunities: Extracellular Vesicles in Biological and Biochemical Processes, 2nd Edition

edited by

Ilaria Giusti

and

Celeste Caruso Bavisotto

submission deadline 15 Apr 2025 | Viewed by 27 | Submission Open

Keywords: extracellular vesicles; exosomes intercellular; crosstalk liquid biopsy carcinogenesis; cell differentiation tissue; homeostasis; organ remodeling; biomedicine; advanced diagnostics

(This special issue belongs to the Section Molecular Immunology)

Life’s Thermodynamics: Cells and Evolution

edited by

Alberto Schiraldi

submission deadline 15 Apr 2025 | Viewed by 20 | Submission Open

Keywords: cell growth and decay; cell aging; system biology; mathematical modeling; ecological modeling; dissipative adaptation; maximum power principle; evolution of microbial fitness; energy balance in microbial cultures

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Proteomics and Its Applications in Disease: 2nd Edition

edited by

Lei Zhou

Qingsong Lin

and

Chuen Lam

submission deadline 20 Apr 2025 | 10 articles | Viewed by 16640 | Submission Open

Keywords: proteomics; quantitative proteomics; biomarkers; signaling pathways; post-translational modifications; disease mechanism; novel therapeutic targets

(This special issue belongs to the Section Biochemistry)

Molecular Aspects of Adrenal Diseases and Carcinoma

edited by Tamás Micsík

submission deadline 20 Apr 2025 | 6 articles | Viewed by 7144 | Submission Open

Keywords: adrenal neoplasia; adrenocortical cancer; molecular and genetics; omics; artificial intelligence digital pathology; individualized therapy; prognostication

(This special issue belongs to the Section Molecular Oncology)

Cell Biology and Functions of the Multifunctional Lysyl Oxidase Family of Proteins 2.0

edited by

Philip C. Trackman

submission deadline 20 Apr 2025 | 2 articles | Viewed by 6284 | Submission Open

Keywords: lysyl oxidases; cancer; tumor suppression; bone biology; gene polymorphisms and mutations; collagen cross-linking; elastin cross-linking; fibrosis; aneurysm

(This special issue belongs to the Section Molecular Biology)

Immunomodulatory Molecules in Cancer

edited by

Georgios Pantouris

submission deadline 20 Apr 2025 | 3 articles | Viewed by 5984 | Submission Open

Keywords: cancer; immunomodulatory molecules; mechanism of action; immune system; small-molecule probes; activation/inhibition; biological activity

(This special issue belongs to the Section Molecular Immunology)

Cyclodextrins: Properties and Applications, 2nd Edition

edited by

Miguel A. Esteso

and

Carmen M. Romero

submission deadline 20 Apr 2025 | 6 articles | Viewed by 5841 | Submission Open

Keywords: cyclodextrins; controlled release systems; structure modification; thermodynamic properties; transport properties

(This special issue belongs to the Section Macromolecules)

Functions and Applications of Natural Products

edited by Seung-Hong Lee and

Seon-Heui Cha

submission deadline 20 Apr 2025 | 4 articles | Viewed by 4708 | Submission Open

Keywords: natural products; biomedicine/phytomedicine; biologically active extracts and compounds; pharmacological and toxicological mechanisms of action

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Advances in Skin Diseases 3.0

edited by

Naoko Kanda

submission deadline 20 Apr 2025 | 1 articles | Viewed by 1058 | Submission Open

Keywords: infection; inflammation; molecular; neoplasm; pathogenesis; skin diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms at the Intersection of Protein Synthesis, Cancer, and Immunity

edited by

Joseph Barbi

and

Sarah E. Walker

submission deadline 20 Apr 2025 | Viewed by 346 | Submission Open

Keywords: translation; protein synthesis; immunology; tumor; cancer; immune suppression; initiation; elongation; eukaryotic initiation factors; ribosome

(This special issue belongs to the Section Molecular Immunology)

Inhibitors of PARP to Kill Cancer Cells

edited by

Maria Raposo

submission deadline 20 Apr 2025 | Submission Open

Keywords: DNA repair inhibitor molecules; drug delivery systems; nanoparticles; phototherapy; cancer; DNA damage

(This special issue belongs to the Section Molecular Pharmacology)

Omics Science and Research in Human Health and Disease

edited by Elisa De Paolis

submission deadline 25 Apr 2025 | Viewed by 102 | Submission Open

Keywords: genomics; transcriptomics; proteomics; metabolomics; single-cell analysis; spatial transcriptomics; bioinformatics; multi-omics

(This special issue belongs to the Section Molecular Biology)

Molecular and Cellular Mechanisms of Spinal Cord Injury and Repair

edited by Victoria Moreno-Manzano

submission deadline 25 Apr 2025 | Viewed by 78 | Submission Open

Keywords: spinal cord injury; molecular changes; neuronal degeneration; circuit regeneration; transcriptomics; cell imaging; single-cell analysis; cell communication; behavior; functional outputs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetic Testing in Molecular Pathology and Diagnosis

edited by

Marco Fabiani

submission deadline 25 Apr 2025 | Viewed by 55 | Submission Open

Keywords: genetic testing; molecular pathology; personalized medicine; genetic diagnostics; disease mechanisms; novel genetic tests; clinical integration; patient management

(This special issue belongs to the Section Molecular Biology)

Effects of Ionizing Radiation in Cancer Radiotherapy: 2nd Edition

edited by

François Chevalier

submission deadline 25 Apr 2025 | Viewed by 39 | Submission Open

Keywords: non-targeted effects; radiation-induced bystander effect; abscopal effect; genomic instability; low dose effects; radioprotection; circulating biomarkers; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Cellular Mechanisms in Cardiomyopathy

edited by

Susan Currie

and Niall MacQuaide

submission deadline 30 Apr 2025 | Viewed by 117 | Submission Open

Keywords: E-C coupling; cardiac myocyte; cardiac fibroblast; ryanodine receptor; SERCA2a; CaMKII; phosphodiesterase

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances of Free-Radical Reactions in Organic Chemistry

edited by

José Justicia

submission deadline 30 Apr 2025 | Viewed by 86 | Submission Open

Keywords: free-radical reactions; organic chemistry; organic synthesis; fotoredox reactions; organometallics reactions; computational calculations; free radicals in biology; free radicals in green chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Pharmacology and Toxicology of Synthetic and Natural Products

edited by

Sherif T. S. Hassan

submission deadline 30 Apr 2025 | Viewed by 54 | Submission Open

Keywords: pharmacology and toxicology; pharmacodynamics and pharmacokinetics; synthetic drugs; natural products; drug interactions; molecular mechanisms; therapeutic potential; adverse effects; dose– response relationship; drug safety and efficacy

(This special issue belongs to the Section Molecular Pharmacology)

Heart Failure Risk Factors and Therapies-Molecular Basis

edited by

Tomasz Urbanowicz

submission deadline 30 Apr 2025 | Viewed by 28 | Submission Open

Keywords: heart failure; risk factors; inflammatory; neutrophils; cytokines; pharmacological; therapies; molecular-based processes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Perspectives on Prostate Cancer Occurrence, Diagnosis, and Treatment

edited by

Michele Marchioni

and

Luigi Schips