MASLD and Its Comorbidities: From Pathophysiology Perspectives
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 9 May 2025 | Viewed by 37
Special Issue Editor
2. Diabetes, Nutrition and Metabolic Diseases Outpatient Unit, Emergency County Clinical Hospital, 540136 Târgu Mureş, Romania
Interests: diabetes mellitus; beta cell; MASLD; fat; leptin
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most common chronic liver disease worldwide, currently affecting over 30% of the adult population. It has lately drawn increasing attention due to its prevalence, increased risk of hepatic and extrahepatic outcomes, and its intricate relationships with other metabolic disorders.
MASLD is part of a multisystem disease with systemic insulin resistance and associated metabolic dysfunctions at its core, which play an important role in the pathogenesis of MASLD and its comorbidities/complications. The association of MASLD with the other metabolic diseases (i.e., type 2 diabetes, obesity, dyslipidemia) significantly increases the risk of extrahepatic and liver‐related outcomes, including malignancy (advanced fibrosis/cirrhosis, hepatocellular carcinoma).
A better understanding of the pathogenetic mechanisms is essential for the prevention of progression towards the more advanced stages of the disease and improved therapeutic interventions. In addition, the changes of terminology and diagnostic criteria of a metabolic liver disease from NAFLD to MAFLD and then MASLD requires the reappraisal of evidence starting from epidemiological data to associations with the risk of developing hepatic and extrahepatic complications and, eventually, to the efficacy of various therapies.
This Dual-Section Special Issue will explore a broader range of MASLD-related topics starting from epidemiology and pathogenetic mechanisms, including those associated with a higher risk of complications, to therapy and patient outcomes. Its aim is to better outline MASLD’s characteristics and the relationship between MASLD and its comorbidities/complications.
This Special Issue will include papers that that apply translational research to explore the cellular and molecular mechanisms related to MASLD, integrative physiology, disease pathogenesis of MASLD and its complications/comorbidities, diagnostic tests and biomarkers.
Prof. Dr. Simona Cernea
Guest Editor
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Keywords
- MASLD
- integrative physiology
- pathogenesis
- biomarkers
- translational research
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